Cited 19 times in
Comparison Between a β-Tricalcium Phosphate and an Absorbable Collagen Sponge Carrier Technology for rhGDF-5–Stimulated Periodontal Wound Healing/Regeneration
DC Field | Value | Language |
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dc.contributor.author | 김종관 | - |
dc.contributor.author | 이중석 | - |
dc.contributor.author | 정의원 | - |
dc.date.accessioned | 2014-12-18T08:57:00Z | - |
dc.date.available | 2014-12-18T08:57:00Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0022-3492 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/87252 | - |
dc.description.abstract | Background: The objective of this study is to compare a candidate β-tricalcium phosphate (β-TCP) carrier technology with the absorbable collagen sponge (ACS) benchmark to support recombinant human growth/differentiation factor-5 (rhGDF-5)–stimulated periodontal wound healing/regeneration. Methods: Routine, bilateral, critical-size (5-mm), 1-wall, intrabony periodontal defects were surgically created in the mandibular premolar region in 10 beagle dogs. Five animals received rhGDF-5/β-TCP and five animals received rhGDF-5/ACS, with a total of 20 μg rhGDF-5 per defect. The animals were euthanized for histologic and histometric analyses at 8 weeks postsurgery. Results: Both rhGDF-5/ACS and rhGDF-5/β-TCP stimulated the formation of functionally oriented periodontal ligament, cellular mixed fiber cementum, and woven/lamellar bone. Bone regeneration (height and area) was significantly greater for the rhGDF-5/β-TCP construct than for the rhGDF-5/ACS (3.26 ± 0.30 mm versus 2.22 ± 0.82 mm, P <0.01; and 10.45 ± 2.26 mm2 versus 5.62 ± 2.39 mm2, P <0.01, respectively). Cementum formation ranged from 3.83 ± 0.73 mm to 3.03 ± 1.18 mm without significant differences between groups. Root resorption/ankylosis was not observed. Conclusions: The β-TCP carrier technology significantly enhanced rhGDF-5–stimulated bone formation compared with the ACS benchmark in this discriminating periodontal defect model. The structural integrity of the β-TCP carrier, preventing compression while providing a framework for bone ingrowth, may account for the observed results. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF PERIODONTOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Alveolar Bone Loss/pathology | - |
dc.subject.MESH | Alveolar Bone Loss/surgery* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bone Marrow/drug effects | - |
dc.subject.MESH | Bone Marrow/pathology | - |
dc.subject.MESH | Bone Regeneration/drug effects | - |
dc.subject.MESH | Calcium Phosphates/chemistry* | - |
dc.subject.MESH | Cementogenesis/drug effects | - |
dc.subject.MESH | Collagen/chemistry* | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Dogs | - |
dc.subject.MESH | Growth Differentiation Factor 5/therapeutic use* | - |
dc.subject.MESH | Guided Tissue Regeneration, Periodontal/methods* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mandible/pathology | - |
dc.subject.MESH | Mandible/surgery | - |
dc.subject.MESH | Osteogenesis/drug effects | - |
dc.subject.MESH | Periodontal Ligament/drug effects | - |
dc.subject.MESH | Periodontal Ligament/pathology | - |
dc.subject.MESH | Recombinant Proteins | - |
dc.subject.MESH | Surgical Flaps | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Tissue Engineering/methods | - |
dc.subject.MESH | Tissue Scaffolds/chemistry* | - |
dc.title | Comparison Between a β-Tricalcium Phosphate and an Absorbable Collagen Sponge Carrier Technology for rhGDF-5–Stimulated Periodontal Wound Healing/Regeneration | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Periodontology (치주과학) | - |
dc.contributor.googleauthor | Young-Taek Kim | - |
dc.contributor.googleauthor | Ulf M.E. Wikesjö | - |
dc.contributor.googleauthor | Ui-Won Jung | - |
dc.contributor.googleauthor | Jung-Seok Lee | - |
dc.contributor.googleauthor | Tae-Gyun Kim | - |
dc.contributor.googleauthor | Chong-Kwan Kim | - |
dc.identifier.doi | 10.1902/jop.2012.120307 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03692 | - |
dc.contributor.localId | A03185 | - |
dc.contributor.localId | A00914 | - |
dc.relation.journalcode | J01697 | - |
dc.identifier.eissn | 1943-3670 | - |
dc.identifier.pmid | 22897651 | - |
dc.identifier.url | http://www.joponline.org/doi/abs/10.1902/jop.2012.120307?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed& | - |
dc.subject.keyword | Alveolar Bone Loss/pathology | - |
dc.subject.keyword | Alveolar Bone Loss/surgery* | - |
dc.subject.keyword | Animals | - |
dc.subject.keyword | Bone Marrow/drug effects | - |
dc.subject.keyword | Bone Marrow/pathology | - |
dc.subject.keyword | Bone Regeneration/drug effects | - |
dc.subject.keyword | Calcium Phosphates/chemistry* | - |
dc.subject.keyword | Cementogenesis/drug effects | - |
dc.subject.keyword | Collagen/chemistry* | - |
dc.subject.keyword | Disease Models, Animal | - |
dc.subject.keyword | Dogs | - |
dc.subject.keyword | Growth Differentiation Factor 5/therapeutic use* | - |
dc.subject.keyword | Guided Tissue Regeneration, Periodontal/methods* | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Mandible/pathology | - |
dc.subject.keyword | Mandible/surgery | - |
dc.subject.keyword | Osteogenesis/drug effects | - |
dc.subject.keyword | Periodontal Ligament/drug effects | - |
dc.subject.keyword | Periodontal Ligament/pathology | - |
dc.subject.keyword | Recombinant Proteins | - |
dc.subject.keyword | Surgical Flaps | - |
dc.subject.keyword | Time Factors | - |
dc.subject.keyword | Tissue Engineering/methods | - |
dc.subject.keyword | Tissue Scaffolds/chemistry* | - |
dc.contributor.alternativeName | Kim, Chong Kwan | - |
dc.contributor.alternativeName | Lee, Jung Seok | - |
dc.contributor.alternativeName | Jung, Ui Won | - |
dc.contributor.affiliatedAuthor | Jung, Ui Won | - |
dc.contributor.affiliatedAuthor | Lee, Jung Seok | - |
dc.contributor.affiliatedAuthor | Kim, Chong Kwan | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 84 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 812 | - |
dc.citation.endPage | 820 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PERIODONTOLOGY, Vol.84(6) : 812-820, 2013 | - |
dc.identifier.rimsid | 32928 | - |
dc.type.rims | ART | - |
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