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The Expression of Glut-1, CAIX, and MCT4 in Mucinous Carcinoma

Title
 The Expression of Glut-1, CAIX, and MCT4 in Mucinous Carcinoma 
Authors
 Sewha Kim ; Woo Hee Jung ; Ja Seung Koo 
Issue Date
2013
Journal Title
 Journal of Breast Cancer (한국유방암학회지) 
ISSN
 1738-6756 
Citation
 Journal of Breast Cancer (한국유방암학회지), Vol.16(2) : 146~151, 2013 
Abstract
PURPOSE: The aim of this study was to assess the expression of metabolism-related proteins including glucose transporter 1 (Glut-1), carbonic anhydrase IX (CAIX) and monocarboxylate transporter 4 (MCT4) in breast mucinous carcinoma and to evaluate the implications of the results. METHODS: Immunohistochemical staining for Glut-1, CAIX, and MCT4 was performed on tissue sections from 59 cases of mucinous carcinoma to evaluate the association between the expression of metabolism-related proteins and clinicopathologic factors. Mucinous carcinoma was subclassified into type A and type B according to histopathological characteristics. RESULTS: Of the 59 patients, 35 patients (59.3%) were type A mucinous carcinoma and 24 patients (40.7%) were type B mucinous carcinoma. Stromal expression of MCT4 was significantly associated with a high histologic grade (p=0.022) and type B mucinous carcinoma (p=0.016). There were significant positive correlations between the expression of Glut-1, CAIX and tumoral expression of MCT4 (p<0.05). CONCLUSION: We assessed the expression of metabolism-related proteins including Glut-1, CAIX, and MCT4 in breast mucinous carcinoma and found that the stromal expression of MCT4 was higher in type B mucinous carcinoma than in type A, which reflected a difference in the tumor microenvironment.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/87203
DOI
10.4048/jbc.2013.16.2.146
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
Yonsei Authors
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