Relationship of low- and high-density lipoproteins to coronary artery plaque composition by CT angiography
Ryo Nakazato ; Heidi Gransar ; James K. Min ; Jonathon Leipsic ; Yong-Jin Kim ; Gudrun Feuchtner ; Ricardo C. Cury ; Allison Dunning ; Todd C. Villines ; Leslee J. Shaw ; Gilbert Raff ; Erica Maffei ; Philipp Kaufmann ; Joerg Hausleiter ; Martin Hadamitzky ; Augustin Delago ; Benjamin J.W. Chow ; Kavitha Chinnaiyan ; Hyuk-Jae Chang ; Tracy Q. Callister ; Filippo Cademartiri ; Matthew J. Budoff ; Mouaz Al-Mallah ; Stephan Achenbach ; Fay Y. Lin ; Victor Y. Cheng ; Daniel S. Berman
Journal of Cardiovascular Computed Tomography, Vol.7(2) : 83~90, 2013
Journal of Cardiovascular Computed Tomography
The association between lipoprotein levels and coronary plaque composition is not well understood.
The aim of this prospective international multicenter study of statin-naive individuals was to evaluate the association of low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol (TC) to coronary plaque composition by coronary computed tomographic angiography (CTA).
We studied 4575 individuals without known coronary artery disease not taking statin medications who underwent coronary CTA. Comparisons were made between those with high versus low LDL, HDL, TC, and non-HDL. We assessed the relationship of lipoproteins and plaques of specific composition (noncalcified [NCP], partially calcified [PCP], or calcified [CP] plaque).
Mean age was 57 ± 11 years (55% men). In univariable analyses, high LDL, low HDL, high TC, and high non-HDL were each associated with increased prevalence of NCPs, PCPs, and CPs (P < 0.05 for all). In multivariable analyses, high non-HDL was associated with the presence of NCP (odds ratio, 1.47; 95% CI, 1.22-1.78: P < 0.001). In the further subanalysis, a weak relationship between the highest group of non HDL (≥190 mg/dL) and the presence of CP was also noted (odds ratio, 1.33; 95% CI, 1.01-1.76; P = 0.04). Further, high non-HDL was associated with increasing numbers of segments with NCP (β coefficient, 0.043; 95% CI, 0.021-0.065; P < 0.001) but not segments with PCP or CP.
NCP presence and extent are associated with high non-HDL. These results suggest a relationship between lipid profile and plaque composition.