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Serum carcinoembryonic antigen is associated with non-alcoholic fatty liver disease in healthy Korean non-smokers

Title
Serum carcinoembryonic antigen is associated with non-alcoholic fatty liver disease in healthy Korean non-smokers
Authors
Jee-Yon Lee;Duk-Chul Lee;Ji-Won Lee
Issue Date
2013
Journal Title
Clinical Chemistry and Laboratory Medicine
ISSN
1434-6621
Citation
Clinical Chemistry and Laboratory Medicine, Vol.51(7) : 1499~1504, 2013
Abstract
BACKGROUND: Carcinoembryonic antigen (CEA), a biomarker overexpressed in malignant tumors, exhibits increased levels in certain non-malignant conditions, including chronic inflammatory status. The elevation of CEA in chronic inflammatory conditions suggests that this marker may also be associated with non-alcoholic fatty liver disease (NAFLD). Therefore, we investigated the relationship between serum CEA concentrations and NAFLD in healthy Korean non-smokers. METHODS: A total of 200 healthy Korean non-smokers were enrolled during their routine health check-ups. Biomarkers of metabolic risk factors were assessed along with the presence of NAFLD using the liver Fibroscan®. Serum CEA levels were measured using a chemiluminescence immunoassay analyzer. RESULTS: The prevalence of NAFLD increased significantly with increasing CEA quartiles; the mean log CEA level increased gradually according to the grade of hepatic steatosis. Multivariate logistic regression analysis adjusted for age, gender, body mass index, exercise, blood pressure, fasting glucose, insulin, total cholesterol, triglycerides, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, white blood cell counts, aspartate aminotransferase, alanine aminotransferase and γ-glutamyltransferase showed that the fourth CEA quartile was associated with NAFLD, with an odds ratio of 2.98 (95% confidence interval 1.10-8.05, p<0.01). CONCLUSIONS: Our study showed independent associations between CEA and NAFLD by analyzing data from 200 healthy Korean non-smokers, suggesting that CEA functions in the pathophysiology of fatty liver disease. Further studies are required to better understand the clinical and pathophysiological significance of our findings.
URI
http://www.degruyter.com/view/j/cclm.2013.51.issue-7/cclm-2012-0585/cclm-2012-0585.xml

http://ir.ymlib.yonsei.ac.kr/handle/22282913/87045
DOI
10.1515/cclm-2012-0585
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Family Medicine
Yonsei Authors
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