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초점분절사구체경화증에서 발세포병증과 형태 변화

Title
 초점분절사구체경화증에서 발세포병증과 형태 변화
Other Titles
 Podocytopathy and Morphologic Changes in Focal Segmental Glomerulosclerosis
Authors
 정현주
Issue Date
2013
Journal Title
 대한소아신장학회지
ISSN
 1226-5292
Citation
 대한소아신장학회지, Vol.17(1) : 13~18, 2013
Abstract
Podocytopathy is glomerular lesions characterized by podocyte injury. It is observed in various glomerular diseases, but minimal change disease and focal segmental glomerulosclerosis (FSGS) are the prototypes. In this review, morphologic features of podocyte injury and subtypes of FSGS will be reviewed briefly. Effacement of podocyte foot processes is the most common feature of podocyte injury. As podocytic injury progresses, intracytoplasmic vacuoles, subpodocytic cyst, detachment of podocytes from the glomerular basement membrane and apoptosis develop. Glomerular capillary loops in epithelium-denuded area undergo capillary collapse. Synechia and hyalinosis may accompany this lesion. To manifest segmental sclerosis, podocyte loss above a threshold level may be required. Injured podocytes can injure neighboring intact podocytes, and thereby spread injury within the same lobule. FSGS can be categorized into five subtypes by morphologic characteristics; not otherwise specified (NOS), perihilar, cellular, tip, and collapsing types. Each subtype has been reported to show different clinical courses and associated conditions, but there are controversies on its significance. With recent progress in the discovery of genetic abnormalities causing FSGS and plasma permeability factors, we expect to unravel pathophysiology of FSGS and to understand histological sequences leading to FSGS in near future.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86966
DOI
10.3339/jkspn.2013.17.1.13
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
Yonsei Authors
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