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Expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer

Authors
 Sewha Kim ; Do Hee Kim ; Ja Seung Koo ; Woo-Hee Jung 
Citation
 Endocrine-Related Cancer, Vol.20(3) : 339~348, 2013 
Journal Title
 Endocrine-Related Cancer 
ISSN
 1351-0088 
Issue Date
2013
Abstract
The aim of this study was to investigate the expression of glutamine metabolism-related proteins to determine whether glutamine is metabolized differently according to breast cancer molecular subtype. We generated a tissue microarray of 702 breast cancer patients and performed immunohistochemical staining for glutamine metabolism-related proteins, including glutaminase 1 (GLS1 (GLS)), glutamate dehydrogenase (GDH (H6PD)), and amino acid transporter-2 (ASCT2 (SLC1A5)), which were separately evaluated in tumor and stroma compartments and then analyzed by breast cancer molecular subtypes. Breast cancers were classified as follows: 293 luminal A (41.7%), 166 luminal B (23.6%), 67 HER2 type (9.6%), and 176 TNBC (25.1%). HER2 type showed the highest stromal GLS1 (P=0.001), tumoral GDH (P=0.001), stromal GDH (P<0.001), and tumoral ASCT (P<0.001) expression. We identified differential expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer. The highest glutamine metabolic activity was seen in HER2-type breast cancer.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86959
DOI
10.1530/ERC-12-0398
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
Yonsei Authors
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Link
 http://erc.endocrinology-journals.org/content/20/3/339.long
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