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Normal enhanced liver fibrosis (ELF) values in apparently healthy subjects undergoing a health check-up and in living liver donors in South Korea

Authors
 Eun Jin Yoo  ;  Beom Kyung Kim  ;  Seung Up Kim  ;  Jun Yong Park  ;  Do Young Kim  ;  Sang Hoon Ahn  ;  Kwang-Hyub Han  ;  Chae Yoon Chon  ;  Hyon-Suk Kim 
Citation
 LIVER INTERNATIONAL, Vol.33(5) : 706-713, 2013 
Journal Title
LIVER INTERNATIONAL
ISSN
 1478-3223 
Issue Date
2013
MeSH
Biomarkers/blood* ; Body Mass Index ; Female ; Humans ; Linear Models ; Liver Cirrhosis/blood* ; Liver Cirrhosis/diagnosis* ; Liver Cirrhosis/pathology ; Male ; Reference Values ; Republic of Korea ; Sex Factors
Keywords
Biomarkers/blood* ; Body Mass Index ; Female ; Humans ; Linear Models ; Liver Cirrhosis/blood* ; Liver Cirrhosis/diagnosis* ; Liver Cirrhosis/pathology ; Male ; Reference Values ; Republic of Korea ; Sex Factors
Abstract
BACKGROUND:
The enhanced liver fibrosis (ELF) value is a non-invasive serum marker used for assessing liver fibrosis in chronic liver disease. To use the ELF value for the purpose of screening the general population and selecting subpopulations at high risk, it is important to know the normal range of ELF values as a prerequisite.
AIMS:
We aimed to define the normal range of ELF values by recruiting apparently healthy subjects and investigating factors influencing ELF values in subjects with minimal fibrotic burden.
METHODS:
ELF values were determined in a cohort of healthy subjects who underwent a health check-up and in healthy living liver donors who were screened for transplantation. None of subjects suffered from chronic heart disease, diabetes mellitus, metabolic syndrome, hepatitis B, hepatitis C, or human immunodeficiency virus infection, systemic autoimmune disease or liver dysfunction.
RESULTS:
Among 183 subjects analyzed, the normal ELF 5th through 95th percentile range was 5.95-8.73. Body mass index (P = 0.014) and male gender (P = 0.015) showed significant positive correlations with ELF value, whereas age did not. In multivariate linear regression analysis, platelet count was identified as the only independent factor influencing the ELF value (β=-0.006, P = 0.016). When considering the difference in ELF values between genders, the normal range of men was defined to be 6.72-8.93, this was slightly higher than that of women, 5.69-8.67.
CONCLUSIONS:
We identified the normal range of ELF values and found that it can be significantly influenced by platelet count even in the healthy population.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/liv.12136/abstract
DOI
10.1111/liv.12136
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Kim, Beom Kyung(김범경) ORCID logo https://orcid.org/0000-0002-5363-2496
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Yoo, Eun Jin(유은진)
Chon, Chae Yoon(전재윤)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86924
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