Incidence of and risk factors for active tuberculosis in human immunodeficiency virus-infected patients in South Korea
Ku, N. S. ; Choi, Y. H. ; Choi, J. Y. ; Kim, J. M. ; Choi, J. P. ; Kim, Y. K.
International Journal of Tuberculosis and Lung Disease, Vol.17(6) : 777~781, 2013
International Journal of Tuberculosis and Lung Disease
In South Korea, a high-income country with an intermediate tuberculosis (TB) burden and low human immunodeficiency virus (HIV) prevalence, studies on incidence and risk factors of TB in HIV-infected persons have rarely been reported.
To investigate the incidence of and risk factors for active TB in HIV-infected persons in South Korea.
A retrospective analysis was conducted of 1265 HIV-1 infected patients who visited four hospitals in South Korea between 1985 and 2012. We analysed the incidence of TB during the follow-up period. To investigate risk factors associated with active TB, we conducted a 1:2 matched case-control study of HIV-infected patients with newly active TB and controls without active TB who had similar CD4(+) T-cell counts and dates of first visit.
Over a total of 4457 person-years (py), 185 (14.6%) subjects were diagnosed with active TB; the incidence was 4.2 cases/100 py. In multivariate analysis, low body mass index (P = 0.033) and current smoking (P = 0.003) were independent risk factors for TB in HIV-infected patients.
Further strategies on prevention and treatment of active TB among HIV-infected patients should be implemented in South Korea. Encouraging smoking cessation and supporting good nutrition may be ways to reduce the incidence of active TB in HIV-infected patients.