Cited 0 times in

Association of clinical events with everolimus exposure in kidney transplant patients receiving reduced cyclosporine

Title
 Association of clinical events with everolimus exposure in kidney transplant patients receiving reduced cyclosporine
Authors
 Fuad S. Shihab; Diane Cibrik; Helio Tedesco-Silva Jr; Zailong Wang; Catherine Cornu-Artis; James Pattison; Gazi Zibari; Rowan Walker; Mario Carmellini; Yu Seun Kim; Laurence Chan
Issue Date
2013
Journal Title
 Clinical Transplantation
ISSN
 0902-0063
Citation
 Clinical Transplantation, Vol.27(2) : 217~226, 2013
Abstract
BACKGROUND: The association between clinical events and everolimus exposure in patients receiving reduced-exposure calcineurin inhibitor therapy is poorly explored. METHODS: In a pre-planned, descriptive analysis of data from a randomized controlled trial, events were correlated with everolimus trough concentrations in 556 newly transplanted kidney transplant patients receiving everolimus with reduced-exposure cyclosporine (CsA) and steroids. Influence of everolimus exposure on clinical events was stratified according to predefined time-normalized concentrations. RESULTS: The incidence of treated biopsy-proven acute rejection and graft loss at month 12 was highest in patients with everolimus <3 ng/mL (36.4% and 28.6%, respectively, vs. 9.1-15.3% and 0.9-5.0% with higher concentration ranges). A higher mortality rate was observed in patients with an everolimus trough concentration ≥ 12 ng/mL (10.0% vs. 1.7-5.6% with lower concentration ranges). The lowest rates of renal dysfunction (defined as poor renal function [estimated GFR, serum creatinine] or proteinuria), wound healing events, peripheral edema, new-onset diabetes mellitus, hypercholesterolemia and hypertriglyceridemia were generally observed with everolimus trough concentration in the range 3-8 ng/mL and CsA <100 ng/mL. Proteinuria occurred most frequently in patients with very low or very high everolimus trough concentrations. CONCLUSIONS: These results support an exposure-response relationship between clinical events and everolimus trough concentrations in kidney transplant patients receiving reduced-exposure CsA.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86644
DOI
10.1111/ctr.12045.
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
Yonsei Authors
사서에게 알리기
  feedback
Link
 http://onlinelibrary.wiley.com/doi/10.1111/ctr.12045/abstract
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse