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Comparison of meperidine and nefopam for prevention of shivering during spinal anesthesia

Authors
 Yeon A Kim ; Tae Dong Kweon ; Ki-Young Lee ; You Jin Lee ; Hye In Lee ; Myounghwa Kim 
Citation
 Korean Journal of Anesthesiology (대한마취과학회지), Vol.64(3) : 229~233, 2013 
Journal Title
 Korean Journal of Anesthesiology (대한마취과학회지) 
ISSN
 2005-6419 
Issue Date
2013
Abstract
BACKGROUND: Shivering is a frequent event during spinal anesthesia and meperidine is a well-known effective drug for prevention and treatment of shivering. Nefopam is a non-opiate analgesic and also known to have an anti-shivering effect. We compared nefopam with meperidine for efficacy of prevention of shivering during spinal anesthesia. METHODS: Sixty five patients, American Society of Anesthesiologists physical status I or II, aged 20-65 years, scheduled for elective orthopedic surgery under spinal anesthesia were investigated. Patients were randomly divided into two groups, meperidine (Group M, n = 33) and nefopam (Group N, n = 32) groups. Group M and N received meperidine 0.4 mg/kg or nefopam 0.15 mg/kg, respectively, in 100 ml of isotonic saline intravenously. All drugs were infused for 15 minutes by a blinded investigator before spinal anesthesia. Blood pressures, heart rates, body temperatures and side effects were checked before and at 15, 30, and 60 minutes after spinal anesthesia. RESULTS: The incidences and scores of shivering were similar between the two groups. The mean arterial pressures in Group N were maintained higher than in Group M at 15, 30, and 60 minutes after spinal anesthesia. The injection pain was checked in Group N only and its incidence was 15.6%. CONCLUSIONS: We conclude that nefopam can be a good substitute for meperidine for prevention of shivering during spinal anesthesia with more stable hemodynamics, if injection pain is effectively controlled.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86620
DOI
10.4097/kjae.2013.64.3.229
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Anesthesiology and Pain Medicine
Yonsei Authors
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