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2-Hydroxycinnamaldehyde inhibits the epithelial-mesenchymal transition in breast cancer cells

Authors
 Ismail Ahmed Ismail ; Hye Sook Kang ; Byoung-Mog Kwon ; Su-Hyung Hong ; Jong In Yook ; Hyun Sil Kim ; Nam Hee Kim ; Chang Woo Lee ; Jieun Yun ; Hyeyoun Chang ; Heon-Jin Lee 
Citation
 Breast Cancer Research and Treatment, Vol.137(3) : 697~708, 2013 
Journal Title
 Breast Cancer Research and Treatment 
ISSN
 0167-6806 
Issue Date
2013
Abstract
Since epithelial-mesenchymal transition (EMT) plays a critical role in cancer progression and in maintaining cancer stem cell properties, EMT is emerging as a therapeutic target for inhibiting the metastatic progression of cancer cells. 2'-Hydroxycinnamaldehyde (HCA) and its derivative, 2'-benzoyloxycinnamaldehyde, have recently been suggested as promising therapeutic candidates for cancer treatment. The purpose of this study is to investigate the anti-metastatic effect of HCA on breast cancer and the molecular mechanisms by which HCA regulates the transcriptional program during EMT. HCA induces epithelial reversion at nanomolar concentrations by suppressing Snail via the nuclear translocalization of GSK-3β, which results in the transcriptional upregulation of E-cadherin. HCA also activates the transcription factor KLF17, which suppresses Id-1, indicating that HCA inhibits EMT by multiple transcriptional programs. Further, HCA treatment significantly inhibits lung metastasis in a mouse orthotopic breast cancer model. This study demonstrates the anti-metastatic effect of the non-toxic natural compound HCA through attenuation of EMT in a breast cancer model.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86552
DOI
10.1007/s10549-012-2388-7
Appears in Collections:
1. 연구논문 > 5. Research Institutes > Oral Cancer Research Institute
1. 연구논문 > 2. College of Dentistry > Dept. of Oral Pathology
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Link
 http://dx.doi.org/10.1007/s10549-012-2388-7
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