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Sonographic Characteristics Suggesting Papillary Thyroid Carcinoma According to Nodule Size

Title
Sonographic Characteristics Suggesting Papillary Thyroid Carcinoma According to Nodule Size
Authors
Ga Ram Kim;Myung Hyun Kim;Eun-Kyung Kim;Jin Young Kwak;Woong Youn Chung;Hee Jung Moon
Issue Date
2013
Journal Title
Annals of Surgical Oncology
ISSN
1068-9265
Citation
Annals of Surgical Oncology, Vol.20(3) : 906~913, 2013
Abstract
Purpose To determine differences in ultrasonography (US) features suggesting papillary thyroid carcinoma (PTC) between nodules larger than 10 mm (large lesions) and nodules ≤10 mm in diameter (small lesions). Methods We included 1,238 nodules in 1,173 patients that were confirmed through cytology or histopathology between February 2007 and June 2007 in the study. Nodules were divided into large lesions (571 lesions) and small lesions (667 lesions). Sonographic features were defined as composition, echogenicity, margin, calcifications, shape, and vascularity. Logistic regression analyses were performed to determine the odds ratios (OR) of each feature to predict PTC. Results On multivariate analysis, irregular margin (OR = 37.788, P < 0.001), microcalcifications (OR = 17.799, P < 0.001), microlobulated margin (OR = 10.385, P < 0.001), and no vascularity (OR = 5.975, P < 0.001) were independent factors for PTC in the large lesions and irregular margin (OR = 7.185, P < 0.001), microlobulated margin (OR = 5.952, P < 0.001), microcalcifications (OR = 3.722, P < 0.001), marked hypoechogenicity (OR = 2.873, P = 0.004), and taller than wide shape (OR = 2.698, P < 0.001) were independent factors for PTC in the small lesions. Conclusions The OR of each US finding for predicting PTC is different between large and small lesions. Therefore, it would be helpful to weight certain US features according to nodule size when reporting thyroid nodules with different risks of PTC.
URI
http://link.springer.com/article/10.1245/s10434-012-2830-4

http://ir.ymlib.yonsei.ac.kr/handle/22282913/86549
DOI
10.1245/s10434-012-2830-4
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Radiology
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
Yonsei Authors
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