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Local increase in microparticles from the aspirate of culprit coronary arteries in patients with ST-segment elevation myocardial infarction

Authors
 민필기 ; 홍성유 ; 윤영원 ; 이다령 ; 이병권 ; 임세중 ; 정광회 ; 조민희 ; 권혁문 ; 최의영 ; 김종윤 ; 홍범기 
Citation
 Atherosclerosis, Vol.227(2) : 323~328, 2013 
Journal Title
 Atherosclerosis 
ISSN
 0021-9150 
Issue Date
2013
Abstract
OBJECTIVE: It has been reported that the levels of procoagulant microparticles (MPs) are increased in patients with acute coronary syndromes and this may contribute to the formation of intracoronary thrombi. In the current study, we investigated the presence of locally elevated MPs within the culprit coronary arteries of patients with ST-segment elevation myocardial infarction (STEMI). METHODS: The study population consisted of 45 patients with STEMI who underwent primary percutaneous coronary intervention (PCI), and 16 control patients. Before and after PCI, blood samples were collected from the femoral artery and from the culprit coronary arteries. In controls, only peripheral blood was obtained. MPs were measured by a solid-phase capture assay using a commercial kit. The cell origins of MPs were determined by antigenic capture with specific antibodies. RESULTS: Baseline levels of MPs in patients with STEMI were higher than in controls. Before PCI, the levels of MPs were significantly higher in culprit coronary arteries than in peripheral arteries in STEMI patients (20.7 ± 15.5 vs. 14.6 ± 15.4 nM phosphatidylserine (PS) equivalent, p = 0.027). MPs from the culprit coronary artery were significantly reduced after PCI (20.7 ± 15.5 vs. 14.3 ± 14.9 nM PS equivalent, p = 0.010). Similarly, the locally increased levels of endothelial- and platelet-derived MPs within the culprit coronary arteries were significantly decreased after PCI. CONCLUSION: Locally increased levels of MPs in culprit coronary arteries and their significant reduction after successful PCI suggest a potential role in coronary atherothrombosis in the early period of STEMI.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86476
DOI
10.1016/j.atherosclerosis.2013.01.032
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
1. 연구논문 > 1. College of Medicine > Yonsei Biomedical Research Center
1. 연구논문 > 5. Research Institutes > Yonsei Cardiovascular Research Institute
1. 연구논문 > 5. Research Institutes > Cardiovascular Product Evaluation Center
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0021915013000944
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