Cited 39 times in
Genetics of inflammatory bowel diseases: a comparison between Western and Eastern perspectives
DC Field | Value | Language |
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dc.contributor.author | 천재희 | - |
dc.date.accessioned | 2014-12-18T08:30:19Z | - |
dc.date.available | 2014-12-18T08:30:19Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0815-9319 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86433 | - |
dc.description.abstract | Inflammatory bowel disease (IBD) is a chronic relapsing intestinal inflammatory disorder with unidentified causes. Currently, studies indicate that IBD results from a complex interplay between various genetic and environmental factors that produce intestinal inflammation. However, these factors may differ for Asians and Caucasians. Thus, differences in epidemiology, genetic variants, and clinical phenotypes of IBD have been observed between the two populations. Understanding the discrepancies between data from populations with different genetic backgrounds and environmental factors may reveal fundamental aspects of IBD pathogenesis. Accordingly, this review will summarize the current knowledge of IBD genetics studied in Asian countries and compare it with that from Western countries, with special focus on innate bacterial sensing, autophagy, and the interleukin-23 receptor-T helper cell 17 pathway. The epigenetic nature of IBD pathogenesis as well as the pharmacogenetics related to the use of immunomodulators will also be briefly covered. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Anti-Inflammatory Agents/therapeutic use | - |
dc.subject.MESH | Asia/epidemiology | - |
dc.subject.MESH | Asian Continental Ancestry Group/genetics* | - |
dc.subject.MESH | Epigenesis, Genetic | - |
dc.subject.MESH | European Continental Ancestry Group/genetics* | - |
dc.subject.MESH | Gastrointestinal Agents/therapeutic use | - |
dc.subject.MESH | Gene-Environment Interaction* | - |
dc.subject.MESH | Genetic Markers | - |
dc.subject.MESH | Genetic Predisposition to Disease | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Inflammatory Bowel Diseases/drug therapy | - |
dc.subject.MESH | Inflammatory Bowel Diseases/ethnology | - |
dc.subject.MESH | Inflammatory Bowel Diseases/genetics* | - |
dc.subject.MESH | Inflammatory Bowel Diseases/immunology | - |
dc.subject.MESH | Inflammatory Bowel Diseases/microbiology | - |
dc.subject.MESH | Pharmacogenetics | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Western World | - |
dc.title | Genetics of inflammatory bowel diseases: a comparison between Western and Eastern perspectives | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Jae Hee Cheon | - |
dc.identifier.doi | 10.1111/jgh.12053 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04030 | - |
dc.relation.journalcode | J01417 | - |
dc.identifier.eissn | 1440-1746 | - |
dc.identifier.pmid | 23189979 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/jgh.12053/abstract | - |
dc.subject.keyword | Crohn’s disease | - |
dc.subject.keyword | epigenetics | - |
dc.subject.keyword | genetics | - |
dc.subject.keyword | immunomodulator | - |
dc.subject.keyword | inflammatory boweldisease | - |
dc.subject.keyword | ulcerative colitis | - |
dc.contributor.alternativeName | Cheon, Jae Hee | - |
dc.contributor.affiliatedAuthor | Cheon, Jae Hee | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 28 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 220 | - |
dc.citation.endPage | 226 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.28(2) : 220-226, 2013 | - |
dc.identifier.rimsid | 28980 | - |
dc.type.rims | ART | - |
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