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Genetics of inflammatory bowel diseases: a comparison between Western and Eastern perspectives

Title
Genetics of inflammatory bowel diseases: a comparison between Western and Eastern perspectives
Authors
Jae Hee Cheon
Issue Date
2013
Journal Title
Journal of Gastroenterology and Hepatology
ISSN
0815-9319
Citation
Journal of Gastroenterology and Hepatology, Vol.28(2) : 220~226, 2013
Abstract
Inflammatory bowel disease (IBD) is a chronic relapsing intestinal inflammatory disorder with unidentified causes. Currently, studies indicate that IBD results from a complex interplay between various genetic and environmental factors that produce intestinal inflammation. However, these factors may differ for Asians and Caucasians. Thus, differences in epidemiology, genetic variants, and clinical phenotypes of IBD have been observed between the two populations. Understanding the discrepancies between data from populations with different genetic backgrounds and environmental factors may reveal fundamental aspects of IBD pathogenesis. Accordingly, this review will summarize the current knowledge of IBD genetics studied in Asian countries and compare it with that from Western countries, with special focus on innate bacterial sensing, autophagy, and the interleukin-23 receptor-T helper cell 17 pathway. The epigenetic nature of IBD pathogenesis as well as the pharmacogenetics related to the use of immunomodulators will also be briefly covered.
URI
http://onlinelibrary.wiley.com/doi/10.1111/jgh.12053/abstract

http://ir.ymlib.yonsei.ac.kr/handle/22282913/86433
DOI
10.1111/jgh.12053
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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