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The effectiveness of the oncolytic activity induced by Ad5/F35 adenoviral vector is dependent on the cumulative cellular conditions of survival and autophagy

Authors
 김주항 ; 송재진 
Citation
 International Journal of Oncology, Vol.42(4) : 1337~1348, 2013 
Journal Title
 International Journal of Oncology 
ISSN
 1019-6439 
Issue Date
2013
Abstract
To overcome the poor tumor transduction efficiency of adenovirus serotype 5 (Ad5) observed in several types of cancer, the fiber region of Ad5, apart from its tail, was replaced by adenovirus serotype 35 (Ad35). The chimeric Ad5̸F35 adenoviral vector did not exhibit any significant enhancement of transduction efficiency. CD46, a receptor for Ad35, was expressed in relatively small amounts in most of the cancer cells examined. Therefore, we investigated the pivotal factor(s) that render cancer cells susceptible to transduction. We discovered that the tumor transduction efficiency of Ad5/F35 was enhanced in the presence of rapamycin, an autophagy inducer, in some cancer cells. Analysis of survival potential and cell proliferation rates revealed that Ad5/F35 exerted a more pronounced oncolytic effect in cancer cells with higher survival potential in the presence of rapamycin.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86423
DOI
10.3892/ijo.2013.1812
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
1. 연구논문 > 5. Research Institutes > Institute for Cancer Research
Yonsei Authors
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Link
 http://www.spandidos-publications.com/ijo/42/4/1337
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