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Induction of cytokines and growth factors by rapamycin in the microenvironment of brain metastases of lung cancer

Title
 Induction of cytokines and growth factors by rapamycin in the microenvironment of brain metastases of lung cancer 
Authors
 SE HOON KIM ; JUNG EUN LEE ; SANG WON LEE ; SEUNG-HO YANG 
Issue Date
2013
Journal Title
 Oncology Letters 
ISSN
 1792-1074 
Citation
 Oncology Letters, Vol.5(3) : 953~958, 2013 
Abstract
The association between rapamycin and astrocytes in a tumor-bearing mouse model with brain metastases of non-small cell lung cancer (NSCLC) was investigated. For in vitro experiments, NCI-H358, a human lung adenocarcinoma cell line, was co-cultured with immortalized astrocytes, and treated with rapamycin, an mTOR inhibitor. We evaluated the expression of interleukin-1 (IL-1), interleukin-3 (IL-3), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β), insulin-like growth factor-1 (IGF-1), platelet-derived growth factor (PDGF), chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1 (MIP-1) in tumor cells in vivo. Rapamycin is cytotoxic in vitro; however, co-culturing tumor cells and astrocytes induced tumor cell survival. IL-1, IL-3, IL-6, TNF-α, TGF-β, PDGF, MCP-1 and MIP-1 expression were higher in rapamycin-treated mice compared to the control group, however, IGF-1 expression was lower. Notably, treatment with rapamycin before inoculating tumor cells affected cytokine expression in the tumor microenvironment. We suggest that growth factors and cytokines in the tumor microenvironment play a role in the survival of cancer cells in brain metastases.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86410
DOI
10.3892/ol.2013.1135
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
Yonsei Authors
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