Cited 12 times in
The effect of oral prostaglandin analogue on painful diabetic neuropathy: a double-blind, randomized, controlled trial
DC Field | Value | Language |
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dc.contributor.author | 이병완 | - |
dc.contributor.author | 장혁재 | - |
dc.contributor.author | 차봉수 | - |
dc.contributor.author | 최동훈 | - |
dc.contributor.author | 양우익 | - |
dc.contributor.author | 김광준 | - |
dc.date.accessioned | 2014-12-18T08:29:30Z | - |
dc.date.available | 2014-12-18T08:29:30Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1462-8902 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86407 | - |
dc.description.abstract | This study was performed to assess the efficacy of beraprost sodium (BPS) in painful diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus (T2DM) patients. In this randomized clinical trial, 99 T2DM patients (41% male, age 60 ± 6 years) with DPN but without evidence of peripheral artery disease were randomized to receive either BPS (40 µg, tid) or placebo for 8 weeks. The primary end point was the improvement of the total symptom score (TSS), temperature rebound (TR) and nadir to peak (NP) above baseline. After 8 weeks treatment, the change of TSS in the BPS group showed a significant improvement compared to the placebo group (2.80 ± 2.48 vs. 1.60 ± 1.94 points, p = 0.009). Furthermore, the number of patients who showed signs of improvement in TSS and the proportion of patients with 50% relief of symptom was also significantly greater in the BPS group than in the placebo group (83.7 vs. 62%, p = 0.015, 36.2 vs. 14%, p = 0.009, respectively). In conclusion, treatment with BPS significantly improved TSS over an 8-week period. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | DIABETES OBESITY & METABOLISM | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/complications | - |
dc.subject.MESH | Diabetes Mellitus, Type 2/drug therapy* | - |
dc.subject.MESH | Diabetic Neuropathies/drug therapy* | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Epoprostenol/analogs & derivatives* | - |
dc.subject.MESH | Epoprostenol/pharmacology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Vasodilator Agents/pharmacology* | - |
dc.title | The effect of oral prostaglandin analogue on painful diabetic neuropathy: a double-blind, randomized, controlled trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | S. Shin | - |
dc.contributor.googleauthor | K. J. Kim | - |
dc.contributor.googleauthor | H. -J. Chang | - |
dc.contributor.googleauthor | B. -W. Lee | - |
dc.contributor.googleauthor | W. -I. Yang | - |
dc.contributor.googleauthor | B. -S. Cha | - |
dc.contributor.googleauthor | D. Choi | - |
dc.identifier.doi | 10.1111/dom.12010 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02796 | - |
dc.contributor.localId | A03490 | - |
dc.contributor.localId | A03996 | - |
dc.contributor.localId | A04053 | - |
dc.contributor.localId | A02300 | - |
dc.contributor.localId | A00317 | - |
dc.contributor.localId | A02107 | - |
dc.relation.journalcode | J00722 | - |
dc.identifier.eissn | 1463-1326 | - |
dc.identifier.pmid | 22974254 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/dom.12010/abstract | - |
dc.subject.keyword | beraprost | - |
dc.subject.keyword | endothelial dysfunction | - |
dc.subject.keyword | painful diabetic neuropathy | - |
dc.contributor.alternativeName | Lee, Byung Wan | - |
dc.contributor.alternativeName | Chang, Hyuck Jae | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.alternativeName | Shin, Sang Joon | - |
dc.contributor.alternativeName | Yang, Woo Ick | - |
dc.contributor.affiliatedAuthor | Lee, Byung Wan | - |
dc.contributor.affiliatedAuthor | Chang, Hyuck Jae | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Yang, Woo Ick | - |
dc.contributor.affiliatedAuthor | Kim, Kwang Joon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 15 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 185 | - |
dc.citation.endPage | 188 | - |
dc.identifier.bibliographicCitation | DIABETES OBESITY & METABOLISM, Vol.15(2) : 185-188, 2013 | - |
dc.identifier.rimsid | 28962 | - |
dc.type.rims | ART | - |
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