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Targeted chemo-photothermal treatments of rheumatoid arthritis using gold half-shell multifunctional nanoparticles

Authors
 Sun-Mi Lee ; Hyung Joon Kim ; Kyung-Hwa Yoo ; Yong-Beom Park ; Soo-Kon Lee ; Young Nyun Park ; You-Jung Ha 
Citation
 ACS Nano, Vol.7(1) : 50~57, 2013 
Journal Title
 ACS Nano 
ISSN
 1936-0851 
Issue Date
2013
Abstract
We have developed RGD-attached gold (Au) half-shell nanoparticles containing methotrexate (MTX) for the treatment of rheumatoid arthritis (RA), where MTX is the most widely used disease-modifying anti-rheumatic drug (DMARD) for the treatment of RA, and RGD peptide is a targeting moiety for inflammation. Upon near-infrared (NIR) irradiation, heat is locally generated due to Au half-shells, and the drug release rate is enhanced, delivering heat and drug to the inflamed joints simultaneously. RA is a chronic inflammatory disease characterized by synovial inflammation in multiple joints within the penetration depth of NIR light. When combined with NIR irradiation, these nanoparticles containing a much smaller dosage of MTX (1/930 of MTX solution) showed greater therapeutic effects than that of a conventional treatment with MTX solution in collagen-induced arthritic mice. This novel drug delivery system is a good way to maximize therapeutic efficacy and minimize dosage-related MTX side effects in the treatment of RA. Furthermore, these multifunctional nanoparticles could be applied to other DMARDs for RA or other inflammatory diseases.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86361
DOI
10.1021/nn301215q
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
Yonsei Authors
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Link
 http://pubs.acs.org/doi/abs/10.1021/nn301215q
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