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Signet Ring Cell Mixed Histology May Show More Aggressive Behavior Than Other Histologies in Early Gastric Cancer

Title
 Signet Ring Cell Mixed Histology May Show More Aggressive Behavior Than Other Histologies in Early Gastric Cancer
Authors
 Cheal Wung Huh; Da Hyun Jung; Sung Hoon Noh; Jae-Ho Cheong; Seung Ho Choi; Sang In Lee; Hyojin Park; Young Hoon Youn; Sun Och Yoon; Hoguen Kim; Hyunki Kim; Yong Chan Lee; Jie-Hyun Kim
Issue Date
2013
Journal Title
 Journal of Surgical Oncology
ISSN
 0022-4790
Citation
 Journal of Surgical Oncology, Vol.107(2) : 124~129, 2013
Abstract
BACKGROUND: Signet ring cell carcinoma (SRC) of the stomach is known to have different microscopic and biologic characteristics compared to non-SRC. The pathologic report has documented partly SRC component with main histologies. However, the clinical significance of SRC mixture has not been reported. Aim was to investigate clinicopathologic features of mixed-SRC histology in early gastric cancer (EGC). METHODS: Two thousand two hundred eight patients were diagnosed with EGC and underwent surgery. The patients were divided into three groups such as adenocarcinoma with partly SRC (mixed-SRC group), only adenocarcinoma (adenocarcinoma group), and SRC (SRC group). Clinicopathologic characteristics were compared. RESULTS: The SRC group was more associated with younger age, female, mid-body, mucosa-confined, depressed type, lower lymph node metastasis (LNM), lower lymphovascular invasion, and better survival rate than adenocarcinoma group. The mixed-SRC group was more associated with younger age, female, upper-body, and depressed type than adenocarcinoma group, similar to SRC group. However, the mixed-SRC group showed more submucosal invasion, larger size, and higher LNM than other groups. The mixed-SRC component was one of the independent risk factors of LNM. CONCLUSIONS: Mixed-SRC histology in EGC showed more aggressive behavior than other histologies. Clinical considerations of mixed-SRC histology may be helpful to decide on a specific cancer treatment.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86350
DOI
10.1002/jso.23261
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
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Link
 http://onlinelibrary.wiley.com/doi/10.1002/jso.23261/abstract#fn1
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