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Signet Ring Cell Mixed Histology May Show More Aggressive Behavior Than Other Histologies in Early Gastric Cancer

Authors
 Cheal Wung Huh ; Da Hyun Jung ; Sung Hoon Noh ; Jae-Ho Cheong ; Seung Ho Choi ; Sang In Lee ; Hyojin Park ; Young Hoon Youn ; Sun Och Yoon ; Hoguen Kim ; Hyunki Kim ; Yong Chan Lee ; Jie-Hyun Kim 
Citation
 Journal of Surgical Oncology, Vol.107(2) : 124~129, 2013 
Journal Title
 Journal of Surgical Oncology 
ISSN
 0022-4790 
Issue Date
2013
Abstract
BACKGROUND: Signet ring cell carcinoma (SRC) of the stomach is known to have different microscopic and biologic characteristics compared to non-SRC. The pathologic report has documented partly SRC component with main histologies. However, the clinical significance of SRC mixture has not been reported. Aim was to investigate clinicopathologic features of mixed-SRC histology in early gastric cancer (EGC). METHODS: Two thousand two hundred eight patients were diagnosed with EGC and underwent surgery. The patients were divided into three groups such as adenocarcinoma with partly SRC (mixed-SRC group), only adenocarcinoma (adenocarcinoma group), and SRC (SRC group). Clinicopathologic characteristics were compared. RESULTS: The SRC group was more associated with younger age, female, mid-body, mucosa-confined, depressed type, lower lymph node metastasis (LNM), lower lymphovascular invasion, and better survival rate than adenocarcinoma group. The mixed-SRC group was more associated with younger age, female, upper-body, and depressed type than adenocarcinoma group, similar to SRC group. However, the mixed-SRC group showed more submucosal invasion, larger size, and higher LNM than other groups. The mixed-SRC component was one of the independent risk factors of LNM. CONCLUSIONS: Mixed-SRC histology in EGC showed more aggressive behavior than other histologies. Clinical considerations of mixed-SRC histology may be helpful to decide on a specific cancer treatment.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86350
DOI
10.1002/jso.23261
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
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Link
 http://onlinelibrary.wiley.com/doi/10.1002/jso.23261/abstract#fn1
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