Cited 19 times in
Treatment strategy for intracranial primary pure germinoma
DC Field | Value | Language |
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dc.contributor.author | 박은경 | - |
dc.contributor.author | 서창옥 | - |
dc.contributor.author | 심규원 | - |
dc.contributor.author | 조재호 | - |
dc.contributor.author | 김동석 | - |
dc.date.accessioned | 2014-12-18T08:25:21Z | - |
dc.date.available | 2014-12-18T08:25:21Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0256-7040 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86276 | - |
dc.description.abstract | OBJECT: This prospective randomized clinical study will address the efficacy of radiation (RT)-alone and combined with pre-RT chemotherapy (CTX) treatments and propose the novel standard treatment strategy for intracranial primary pure germinoma. MATERIALS AND METHODS: Between 2005 and 2008, there were 54 patients diagnosed with intracranial primary pure germinomas in a single institute. Twenty-eight patients were enrolled. The mean age of the patients was 16.2 years (range 6-31 years). There were 19 men and 9 women (men/women ratio = 2.1:1). There were 21 patients with solitary tumors and 7 with multiple tumors. These patients were randomized as RT-only treatment group (11 solitary and 3 multiple tumors) and combined (10 solitary and 4 multiple tumors, neo-adjuvant CTX followed by response-adapted RT) treatment group. The follow-up period for RT only group has a median of 58 months (mean 58.2 months, range 41-82 months), and for combine therapy group, the median was 68.5 months (mean 67.8 months, range 41-88 months). All 14 patients in the RT-only group showed complete response (CR) and no recurrence. Eleven patients in the combined group had CR and three patients had partial response after neo-adjuvant CTX. All patients responded to RT as CR without recurrence. At the time of analysis, all 28 patients were alive without evidence of disease. CONCLUSION: Neo-adjuvant CTX for localized germinomas seems to be unnecessary as a method to reduce radiation dose in our RT protocol. However, the effective control of multifocal or disseminated germinoma can be achieved by neo-adjuvant CTX followed by response-adapted reduced dose RT. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | CHILDS NERVOUS SYSTEM | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Antineoplastic Agents/administration & dosage* | - |
dc.subject.MESH | Brain Neoplasms/drug therapy* | - |
dc.subject.MESH | Brain Neoplasms/pathology | - |
dc.subject.MESH | Brain Neoplasms/radiotherapy* | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Combined Modality Therapy/methods | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Germinoma/drug therapy* | - |
dc.subject.MESH | Germinoma/pathology | - |
dc.subject.MESH | Germinoma/radiotherapy* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Young Adult | - |
dc.title | Treatment strategy for intracranial primary pure germinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학) | - |
dc.contributor.googleauthor | Kyu-Won Shim | - |
dc.contributor.googleauthor | Eun Kyung Park | - |
dc.contributor.googleauthor | Yoon-Ho Lee | - |
dc.contributor.googleauthor | Chang-Ok Suh | - |
dc.contributor.googleauthor | Jaeho Cho | - |
dc.contributor.googleauthor | Joong-Uhn Choi | - |
dc.contributor.googleauthor | Dong-Seok Kim | - |
dc.identifier.doi | 10.1007/s00381-012-1902-x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01607 | - |
dc.contributor.localId | A01919 | - |
dc.contributor.localId | A02187 | - |
dc.contributor.localId | A00402 | - |
dc.contributor.localId | A03901 | - |
dc.relation.journalcode | J00525 | - |
dc.identifier.eissn | 1433-0350 | - |
dc.identifier.pmid | 22965772 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00381-012-1902-x | - |
dc.subject.keyword | Germ cell tumor | - |
dc.subject.keyword | Germinoma | - |
dc.subject.keyword | Craniospinal irradiation | - |
dc.subject.keyword | Neo-adjuvant chemotherapy | - |
dc.contributor.alternativeName | Park, Eun Kyung | - |
dc.contributor.alternativeName | Suh, Chang Ok | - |
dc.contributor.alternativeName | Shim, Kyu Won | - |
dc.contributor.alternativeName | Cho, Jae Ho | - |
dc.contributor.alternativeName | Kim, Dong Seok | - |
dc.contributor.affiliatedAuthor | Park, Eun Kyung | - |
dc.contributor.affiliatedAuthor | Suh, Chang Ok | - |
dc.contributor.affiliatedAuthor | Shim, Kyu Won | - |
dc.contributor.affiliatedAuthor | Kim, Dong Seok | - |
dc.contributor.affiliatedAuthor | Cho, Jae Ho | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 29 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 239 | - |
dc.citation.endPage | 248 | - |
dc.identifier.bibliographicCitation | CHILDS NERVOUS SYSTEM, Vol.29(2) : 239-248, 2013 | - |
dc.identifier.rimsid | 28885 | - |
dc.type.rims | ART | - |
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