Analysis of 18F-fluorodeoxyglucose positron emission tomography findings in patients with pituitary lesions
Hannah Seok ; Eun Young Lee ; Yumie Rhee ; Sung-Kil Lim ; Eun Jig Lee ; Jong Doo Lee ; Mi Jin Yun ; Tae Sung Kim ; Ho Jin Cho ; Dong Yeob Shin ; Joo Young Kim ; Woo In Yang ; Eun Yeong Choe
Korean Journal of Internal Medicine, Vol.28(1) : 81~88, 2013
Korean Journal of Internal Medicine
Although magnetic resonance imaging (MRI) is a good visual modality for the evaluation of pituitary lesions, it has limited value in the diagnosis of mixed nodules and some cystic lesions. We evaluated the usefulness of 18F-fluorodeoxyglucose positron emission tomography (FDG PET) for patients with pituitary lesions.
18F-FDG PET and MRI were performed simultaneously in 32 consecutive patients with pituitary lesions. The relationships between FDG uptake patterns in PET and MRI findings were analyzed.
Of 24 patients with piuitary adenomas, 19 (79.2%) showed increased uptake of 18F-FDG in the pituitary gland on PET scans. All patients with pituitary macroadenomas showed increased 18F-FDG uptake on PET scans. Meanwhile, only five (50%) of the 10 patients with pituitary microadenomas showed positive PET scans. Interestingly, of two patients with no abnormal MRI findings, one showed increased 18F-FDG uptake on PET. For positive 18F-FDG uptake, maximum standardized uptake values (SUVmax) > 2.4 had 94.7% sensitivity and 100% specificity. In addition, SUVmax increased in proportion to the size of pituitary adenomas. Most cystic lesions did not show 18F-FDG uptake on PET scans.
About 80% of pituitary adenomas showed positivity on PET scans, and SUVmax was related to the size of the adenomas. PET may be used as an ancillary tool for detection and differentiation of pituitary lesions.