3 558

Cited 43 times in

Combination of Pregabalin and Dexamethasone for Postoperative Pain and Functional Outcome in Patients Undergoing Lumbar Spinal Surgery: A Randomized Placebo-controlled Trial

Authors
 Choi Yong Seon  ;  Shim Jae-Kwang  ;  Song Jong Wook  ;  Kim Jong Chan  ;  Yoo Young Chul  ;  Kwak Young Lan 
Citation
 CLINICAL JOURNAL OF PAIN, Vol.29(1) : 9-14, 2013 
Journal Title
CLINICAL JOURNAL OF PAIN
ISSN
 0749-8047 
Issue Date
2013
MeSH
Activities of Daily Living ; Adult ; Aged ; Analgesics/administration & dosage ; Anti-Inflammatory Agents/administration & dosage ; Dexamethasone/administration & dosage* ; Drug Therapy, Combination ; Female ; Humans ; Laminectomy/statistics & numerical data* ; Lumbar Vertebrae/surgery* ; Male ; Middle Aged ; Pain Measurement/drug effects ; Pain Measurement/statistics & numerical data ; Pain, Postoperative/diagnosis ; Pain, Postoperative/drug therapy* ; Pain, Postoperative/epidemiology ; Placebo Effect ; Pregabalin ; Premedication/methods ; Premedication/utilization* ; Recovery of Function ; Republic of Korea/epidemiology ; Treatment Outcome ; Young Adult ; gamma-Aminobutyric Acid/administration & dosage ; gamma-Aminobutyric Acid/analogs & derivatives*
Keywords
dexamethasone ; postoperative pain ; pregabalin
Abstract
OBJECTIVES:
In this randomized-controlled study, we investigated the effects of combined administration of pregabalin and dexamethasone on postoperative pain and analgesic requirements, and functional outcome in patients who underwent lumbar spinal surgery.
METHODS:
One hundred eight patients were randomized to group C (placebo+placebo), group P (pregabalin + placebo), or group PD (pregabalin+dexamethasone). According to their allocated group, patients received placebo or pregabalin 150 mg every 12 hours starting 1 hour before anesthetic induction for a total of 8 doses. Dexamethasone 16 mg or normal saline was injected before the induction of anesthesia. The pain intensity, analgesic requirements, and side effects were assessed in the postoperative period: postanesthesia care unit, 12, 24, 48, and 72 hours. Pain intensity and daily activity performance were also assessed 1, 3, and 6 months after surgery.
RESULTS:
Compared with group C, the pain scores were lower in group PD at 24 hours after surgery (P = 0.011). The frequency of additional rescue analgesic administration was significantly lower in group PD until 48 hours after surgery (P < 0.05) and in group P at 24 to 48 hours (P = 0.005) relative to group C. Back pain intensity at work was lower (P = 0.048) and daily activity performance was better (P = 0.006) in group PD compared with group C at 1 month after surgery.
CONCLUSIONS:
Combined administration of pregabalin and dexamethasone conferred analgesic benefits superior to those of pregabalin alone. This regimen also helped facilitate return to normal daily activity after surgery.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00002508-201301000-00003&LSLINK=80&D=ovft
DOI
10.1097/AJP.0b013e318246d1a9
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Young Lan(곽영란) ORCID logo https://orcid.org/0000-0002-2984-9927
Song, Jong Wook(송종욱) ORCID logo https://orcid.org/0000-0001-7518-2070
Shim, Jae Kwang(심재광) ORCID logo https://orcid.org/0000-0001-9093-9692
Yoo, Young Chul(유영철) ORCID logo https://orcid.org/0000-0002-6334-7541
Choi, Yong Seon(최용선) ORCID logo https://orcid.org/0000-0002-5348-864X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86224
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links