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Inhibition of PKMzeta in the nucleus accumbens core blocks the expression of locomotor sensitization induced by amphetamine

Title
Inhibition of PKMzeta in the nucleus accumbens core blocks the expression of locomotor sensitization induced by amphetamine
Authors
Min Ji Song;Ju Kyong Jang;Jeong-Hoon Kim;Hyung Shin Yoon;Wha Young Kim
Issue Date
2013
Journal Title
Behavioural Brain Research
ISSN
0166-4328
Citation
Behavioural Brain Research, Vol.241(null) : 139~143, 2013
Abstract
Behavioral sensitization is a form of drug-induced, long-lasting, non-associative memory. Protein kinase M zeta (PKMζ) has been shown to play a role in maintaining associative long-term memory in various brain regions. In the present study, rats were pre-exposed to either saline or amphetamine (AMPH) (1 mg/kg, i.p.). After 1 week of drug-free withdrawal period, they were challenged with AMPH (1 mg/kg, i.p.) following a bilateral microinjection of either saline or zeta inhibitory peptide (ZIP) (5 nmole/side) into the NAcc core. In the AMPH pre-exposed group, the ZIP microinjection blocked the enhanced increase of locomotion by AMPH challenge. These results suggest that PKMζ in the NAcc core plays a role in the expression of AMPH-induced locomotor sensitization, and further extend the role of PKMζ in long-term memory to non-associative form of drug-related memory.
URI
http://www.sciencedirect.com/science/article/pii/S0166432812007814

http://ir.ymlib.yonsei.ac.kr/handle/22282913/86196
DOI
10.1016/j.bbr.2012.12.007
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Physiology
Yonsei Authors
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