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Inhibition of PKMzeta in the nucleus accumbens core blocks the expression of locomotor sensitization induced by amphetamine

Authors
 Min Ji Song ; Ju Kyong Jang ; Jeong-Hoon Kim ; Hyung Shin Yoon ; Wha Young Kim 
Citation
 Behavioural Brain Research, Vol.241(null) : 139~143, 2013 
Journal Title
 Behavioural Brain Research 
ISSN
 0166-4328 
Issue Date
2013
Abstract
Behavioral sensitization is a form of drug-induced, long-lasting, non-associative memory. Protein kinase M zeta (PKMζ) has been shown to play a role in maintaining associative long-term memory in various brain regions. In the present study, rats were pre-exposed to either saline or amphetamine (AMPH) (1 mg/kg, i.p.). After 1 week of drug-free withdrawal period, they were challenged with AMPH (1 mg/kg, i.p.) following a bilateral microinjection of either saline or zeta inhibitory peptide (ZIP) (5 nmole/side) into the NAcc core. In the AMPH pre-exposed group, the ZIP microinjection blocked the enhanced increase of locomotion by AMPH challenge. These results suggest that PKMζ in the NAcc core plays a role in the expression of AMPH-induced locomotor sensitization, and further extend the role of PKMζ in long-term memory to non-associative form of drug-related memory.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86196
DOI
10.1016/j.bbr.2012.12.007
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Physiology
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0166432812007814
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