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Impact of Diabetes on Oncologic Outcome of Colorectal Cancer Patients: Colon vs. Rectal Cancer

Title
Impact of Diabetes on Oncologic Outcome of Colorectal Cancer Patients: Colon vs. Rectal Cancer
Authors
Justin Y. Jeon;Duck Hyoun Jeong;Nam Kyu Kim;Jeffrey A. Meyerhardt;Jennifer A. Ligibel;Kaori Sato;Mi Kyung Lee;Ji-Hye Park;Sang Hui Chu;Ji-Won Lee;Min Geun Park
Issue Date
2013
Journal Title
PLoS One
ISSN
1932-6203
Citation
PLoS One, Vol.8(2) : e55196, 2013
Abstract
BACKGROUND: To evaluate the impact of diabetes on outcomes in colorectal cancer patients and to examine whether this association varies by the location of tumor (colon vs. rectum). PATIENTS AND METHODS: This study includes 4,131 stage I-III colorectal cancer patients, treated between 1995 and 2007 (12.5% diabetic, 53% colon, 47% rectal) in South Korea. Cox proportional hazards modeling was used to determine the prognostic influence of DM on survival endpoints. RESULTS: Colorectal cancer patients with DM had significantly worse disease-free survival (DFS) [hazard ratio (HR) 1.17, 95% confidence interval (CI): 1.00-1.37] compared with patients without DM. When considering colon and rectal cancer independently, DM was significantly associated with worse overall survival (OS) (HR: 1.46, 95% CI: 1.11-1.92), DFS (HR: 1.45, 95% CI: 1.15-1.84) and recurrence-free survival (RFS) (HR: 1.32, 95% CI: 0.98-1.76) in colon cancer patients. No association for OS, DFS or RFS was observed in rectal cancer patients. There was significant interaction of location of tumor (colon vs. rectal cancer) with DM on OS (P = 0.009) and DFS (P = 0.007). CONCLUSIONS: This study suggests that DM negatively impacts survival outcomes of patients with colon cancer but not rectal cancer.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/86193
DOI
10.1371/journal.pone.0055196
Appears in Collections:
1. 연구논문 > 3. College of Nursing > Dept. of Nursing Environment Systems
1. 연구논문 > 1. College of Medicine > Dept. of Family Medicine
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
Yonsei Authors
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