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Serum carcinoembryonic antigen level is associated with arterial stiffness in healthy Korean adult

Authors
 Urhee Bae ; Jae Yong Shim ; Jin Young Shin ; Hye Ree Lee 
Citation
 Clinica Chimica Acta, Vol.415 : 286~289, 2013 
Journal Title
 Clinica Chimica Acta 
ISSN
 0009-8981 
Issue Date
2013
Abstract
BACKGROUND: Carcinoembryonic antigen (CEA), a widely used tumor marker, has been reported to be related with atherosclerosis and cardiovascular disease. However, little is known about the relationship between arterial stiffness and CEA level. We assessed whether serum CEA level is related with arterial stiffness by measuring brachial-ankle pulse wave velocity (ba-PWV) in healthy subjects. METHODS: Serum CEA level, ba-PWV and conventional risk factors were measured in 2909 subjects (1767 men and 1142 women) who underwent routine health checkup. We performed correlation, multiple linear regression and multiple logistic regression analyses to divide into quartiles according to CEA level. RESULTS: The mean values of ba-PWV increased gradually by CEA quartile. After correcting for significantly correlated variables, the ba-PWV was independently associated with CEA (P<0.001). The odds ratios (95% CI) for high ba-PWV (>75th percentile; men: 1518 cm/s, women: 1487 cm/s) according to CEA quartile were 1.00 (Q1), 1.044 (0.659-1.652; Q2), 1.075 (0.688-1.681; Q3), and 1.595 (1.009-2.520; Q4) after adjusting for age, blood pressure, BMI, fasting glucose, heart rate, log hs-CRP, LDL-cholesterol, WBC count, alcohol intake, smoking and exercise in men (P<0.001). The odds ratios (95% CIs) in women were 1.00 (Q1), 1.719 (0.971-3.032; Q2), 1.793 (1.019-3.156; Q3), and 2.330 (1.312-4.139; Q4) (P<0.001) after adjusting for age, blood pressure, BMI, fasting glucose, heart rate, log hs-CRP, lipid profile, uric acid, WBC count, alcohol intake, smoking and exercise. CONCLUSIONS: The CEA level is associated with arterial stiffness which measured by ba-PWV in healthy Korean men and women.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86164
DOI
10.1016/j.cca.2012.10.052
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Family Medicine
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0009898112005244
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