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Effect of high-dose vitamin C on renal ischemia-reperfusion injury
DC Field | Value | Language |
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dc.contributor.author | 고서희 | - |
dc.contributor.author | 곽영란 | - |
dc.contributor.author | 신은아 | - |
dc.contributor.author | 심재광 | - |
dc.contributor.author | 전지혜 | - |
dc.date.accessioned | 2024-04-18T08:16:40Z | - |
dc.date.available | 2024-04-18T08:16:40Z | - |
dc.date.issued | 2024-03 | - |
dc.identifier.issn | 0753-3322 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198884 | - |
dc.description.abstract | Acute kidney injury frequently occurs after cardiac surgery, and is primarily attributed to renal ischemia?reperfusion (I/R) injury and inflammation from surgery and cardiopulmonary bypass. Vitamin C, an antioxi?dant that is often depleted in critically ill patients, could potentially mitigate I/R-induced oxidative stress at high doses. We investigated the effectiveness of high-dose vitamin C in preventing I/R-induced renal injury. The ideal time and optimal dosage for administration were determined in a two-phase experiment on Sprague–Dawley rats. The rats were assigned to four groups: sham, IRC (I/R + saline), and pre- and post-vitC (vitamin C before and after I/R, respectively), with vitamin C administered at 200 mg/kg. Additional groups were examined for dose modification based on the optimal timing determined: V100, V200, and V300 (100, 200, and 300 mg/kg, respectively). Renal I/R was achieved through 45 min of ischemia followed by 24 h of reperfusion. Vitamin C administration during reperfusion significantly reduced renal dysfunction and tubular damage, more than pre?ischemic administration. Doses of 100 and 200 mg/kg during reperfusion reduced oxidative stress markers, including myeloperoxidase and inflammatory responses by decreasing high mobility group box 1 release and nucleotide-binding and oligomerization domain-like receptor 3 inflammasome. Overall beneficial effect was most prominent with 200 mg/kg. The 300 mg/kg dose, however, showed no additional benefits over the IRC group regarding serum blood urea nitrogen and creatinine levels and histological evaluation. During reperfusion, high-dose vitamin C administration (200 mg/kg) significantly decreased renal I/R injury by effectively attenu?ating the major triggers of oxidative stress and inflammation. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English, French | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | BIOMEDICINE & PHARMACOTHERAPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Acute Kidney Injury* / metabolism | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antineoplastic Agents* / pharmacology | - |
dc.subject.MESH | Ascorbic Acid / metabolism | - |
dc.subject.MESH | Ascorbic Acid / pharmacology | - |
dc.subject.MESH | Ascorbic Acid / therapeutic use | - |
dc.subject.MESH | Creatinine | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Inflammation / metabolism | - |
dc.subject.MESH | Ischemia / metabolism | - |
dc.subject.MESH | Kidney | - |
dc.subject.MESH | Oxidative Stress | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Reperfusion Injury* / pathology | - |
dc.title | Effect of high-dose vitamin C on renal ischemia-reperfusion injury | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) | - |
dc.contributor.googleauthor | Seo Hee Ko | - |
dc.contributor.googleauthor | Ji Hae Jun | - |
dc.contributor.googleauthor | Ju Eun Oh | - |
dc.contributor.googleauthor | Eunah Shin | - |
dc.contributor.googleauthor | Young-Lan Kwak | - |
dc.contributor.googleauthor | Jae-Kwang Shim | - |
dc.identifier.doi | 10.1016/j.biopha.2024.116407 | - |
dc.contributor.localId | A05083 | - |
dc.contributor.localId | A00172 | - |
dc.contributor.localId | A05876 | - |
dc.contributor.localId | A02205 | - |
dc.contributor.localId | A03552 | - |
dc.relation.journalcode | J00322 | - |
dc.identifier.eissn | 1950-6007 | - |
dc.identifier.pmid | 38460367 | - |
dc.subject.keyword | Acute kidney injury | - |
dc.subject.keyword | Ascorbic acid | - |
dc.subject.keyword | Ischemia-reperfusion injury | - |
dc.subject.keyword | Vitamin C | - |
dc.contributor.alternativeName | Ko, Seo Hee | - |
dc.contributor.affiliatedAuthor | 고서희 | - |
dc.contributor.affiliatedAuthor | 곽영란 | - |
dc.contributor.affiliatedAuthor | 신은아 | - |
dc.contributor.affiliatedAuthor | 심재광 | - |
dc.contributor.affiliatedAuthor | 전지혜 | - |
dc.citation.volume | 173 | - |
dc.citation.startPage | 116407 | - |
dc.identifier.bibliographicCitation | BIOMEDICINE & PHARMACOTHERAPY, Vol.173 : 116407, 2024-03 | - |
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