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Safety of Administering Intravenous CT Contrast Agents Repeatedly or Using Both CT and MRI Contrast Agents on the Same Day: An Animal Study
DC Field | Value | Language |
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dc.contributor.author | 배희진 | - |
dc.contributor.author | 정용은 | - |
dc.date.accessioned | 2024-04-11T06:35:01Z | - |
dc.date.available | 2024-04-11T06:35:01Z | - |
dc.date.issued | 2024-03 | - |
dc.identifier.issn | 1229-6929 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198820 | - |
dc.description.abstract | Objective: To investigate molecular and functional consequences of additional exposures to iodine- or gadolinium-based contrast agents within 24 hours from the initial intravenous administration of iodine-based contrast agents through an animal study. Materials and Methods: Fifty-six Sprague–Dawley male rats were equally divided into eight groups: negative control, positive control (PC) with single-dose administration of CT contrast agent, and additional administration of either CT or MR contrast agents 2, 4, or 24 hours from initial CT contrast agent injection. A 12 μL/g of iodinated contrast agent or a 0.47 μL/g of gadoliniumbased contrast agent were injected into the tail vein. Serum levels of blood urea nitrogen, creatinine, cystatin C (Cys C), and malondialdehyde (MDA) were measured. mRNA and protein levels of kidney injury molecule-1 (KIM-1) and neutrophil gelatinaseassociated lipocalin (NGAL) were evaluated. Results: Levels of serum creatinine (SCr) were significantly higher in repeated CT contrast agent injection groups than in PC (0.21 ± 0.02 mg/dL for PC; 0.40 ± 0.02, 0.34 ± 0.03, and 0.41 ± 0.10 mg/dL for 2-, 4-, and 24-hour interval groups, respectively; P < 0.001). There was no significant difference in the average Cys C and MDA levels between PC and repeated CT contrast agent injection groups (Cys C, P = 0.256–0.362; MDA, P > 0.99). Additional doses of MR contrast agent did not make significant changes compared to PC in SCr (P > 0.99), Cys C (P = 0.262), and MDA (P = 0.139–0.771) levels. mRNA and protein levels of KIM-1 and NGAL were not significantly different among additional CT or MR contrast agent groups (P > 0.05). Conclusion: A sufficient time interval, probably more than 24 hours, between repeated contrast-enhanced CT examinations may be necessary to avoid deterioration in renal function. However, conducting contrast-enhanced MRI on the same day as contrast-enhanced CT may not induce clinically significant kidney injury. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Society of Radiology | - |
dc.relation.isPartOf | KOREAN JOURNAL OF RADIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Acute Kidney Injury* | - |
dc.subject.MESH | Administration, Intravenous | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Biomarkers | - |
dc.subject.MESH | Contrast Media / adverse effects | - |
dc.subject.MESH | Creatinine | - |
dc.subject.MESH | Gadolinium | - |
dc.subject.MESH | Iodine* | - |
dc.subject.MESH | Kidney | - |
dc.subject.MESH | Lipocalin-2 | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | RNA, Messenger | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Tomography, X-Ray Computed | - |
dc.title | Safety of Administering Intravenous CT Contrast Agents Repeatedly or Using Both CT and MRI Contrast Agents on the Same Day: An Animal Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Heejin Bae | - |
dc.contributor.googleauthor | Hyewon Oh | - |
dc.contributor.googleauthor | Ga Bin Park | - |
dc.contributor.googleauthor | Yong Eun Chung | - |
dc.identifier.doi | 10.3348/kjr.2023.0712 | - |
dc.contributor.localId | A05346 | - |
dc.contributor.localId | A03662 | - |
dc.relation.journalcode | J02884 | - |
dc.identifier.eissn | 2005-8330 | - |
dc.identifier.pmid | 38413110 | - |
dc.subject.keyword | Acute kidney injury | - |
dc.subject.keyword | Computed tomography | - |
dc.subject.keyword | Contrast agent | - |
dc.subject.keyword | Magnetic resonance imaging | - |
dc.contributor.alternativeName | Bae, Heejin | - |
dc.contributor.affiliatedAuthor | 배희진 | - |
dc.contributor.affiliatedAuthor | 정용은 | - |
dc.citation.volume | 25 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 257 | - |
dc.citation.endPage | 266 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF RADIOLOGY, Vol.25(3) : 257-266, 2024-03 | - |
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