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Roles of Inflammatory Biomarkers in Exhaled Breath Condensates in Respiratory Clinical Fields
DC Field | Value | Language |
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dc.contributor.author | 김영삼 | - |
dc.contributor.author | 박혜정 | - |
dc.contributor.author | 변민광 | - |
dc.contributor.author | 최용준 | - |
dc.contributor.author | 이민재 | - |
dc.date.accessioned | 2024-04-11T06:23:42Z | - |
dc.date.available | 2024-04-11T06:23:42Z | - |
dc.date.issued | 2024-01 | - |
dc.identifier.issn | 1738-3536 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198785 | - |
dc.description.abstract | Background: Exhaled condensates contain inflammatory biomarkers; however, their roles in the clinical field have been under-investigated. Methods: We prospectively enrolled subjects admitted to pulmonology clinics. We collected exhaled breath condensates (EBC) and analysed the levels of 6 and 12 biomarkers using conventional and multiplex enzyme-linked immunosorbent assay, respectively. Results: Among the 123 subjects, healthy controls constituted the largest group (81 participants; 65.9%), followed by the preserved ratio impaired spirometry group (21 patients; 17.1%) and the chronic obstructive pulmonary disease (COPD) group (21 patients; 17.1%). In COPD patients, PDGF-AA exhibited strong positive correlations with COPD assessment test (ρ = 0.5926, p = 0.0423) and SGRQ-C score (total, ρ = 0.6725, p = 0.0166; activity, ρ = 0.7176, p = 0.0086; and impacts, ρ = 0.6151, p = 0.0333). Granzyme B showed strong positive correlations with SGRQ-C score (symptoms, ρ = 0.6078, p = 0.0360 and impacts, ρ = 0.6007, p = 0.0389). IL-6 exhibited a strong positive correlation with SGRQ-C score (activity, ρ = 0.4671, p = 0.0378). The absolute serum eosinophil and basophil counts showed positive correlations with pro-collagen I alpha 1 (ρ = 0.6735, p = 0.0164 and ρ = 0.6295, p = 0.0283, respectively). In healthy subjects, FEV1/FVC demonstrated significant correlation with CCL3/MIP-1 alpha (ρ = 0.3897 and p = 0.0068). FEV1 exhibited significant correlation with CCL11/eotaxin (ρ = 0.4445 and p = 0.0017). Conclusions: Inflammatory biomarkers in EBC might be useful to predict quality of life concerning respiratory symptoms and serologic markers. Further studies are needed. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | Korean | - |
dc.publisher | 대한결핵 및 호흡기학회 | - |
dc.relation.isPartOf | TUBERCULOSIS AND RESPIRATORY DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Roles of Inflammatory Biomarkers in Exhaled Breath Condensates in Respiratory Clinical Fields | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Yong Jun Choi | - |
dc.contributor.googleauthor | Min Jae Lee | - |
dc.contributor.googleauthor | Min Kwang Byun | - |
dc.contributor.googleauthor | Sangho Park | - |
dc.contributor.googleauthor | Jimyung Park | - |
dc.contributor.googleauthor | Dongil Park | - |
dc.contributor.googleauthor | Sang-Hoon Kim | - |
dc.contributor.googleauthor | Youngsam Kim | - |
dc.contributor.googleauthor | Seong Yong Lim | - |
dc.contributor.googleauthor | Kwang Ha Yoo | - |
dc.contributor.googleauthor | Ki Suck Jung | - |
dc.contributor.googleauthor | Hye Jung Park | - |
dc.identifier.doi | 10.4046/trd.2023.0028 | - |
dc.contributor.localId | A00707 | - |
dc.contributor.localId | A01769 | - |
dc.contributor.localId | A01848 | - |
dc.contributor.localId | A06061 | - |
dc.relation.journalcode | J02761 | - |
dc.identifier.eissn | 2005-6184 | - |
dc.identifier.pmid | 37822233 | - |
dc.subject.keyword | Chronic Obstructive Pulmonary Disease, Lung Function Test | - |
dc.subject.keyword | Eosinophils | - |
dc.subject.keyword | Exhaled Condensates | - |
dc.contributor.alternativeName | Kim, Young Sam | - |
dc.contributor.affiliatedAuthor | 김영삼 | - |
dc.contributor.affiliatedAuthor | 박혜정 | - |
dc.contributor.affiliatedAuthor | 변민광 | - |
dc.contributor.affiliatedAuthor | 최용준 | - |
dc.citation.volume | 87 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 65 | - |
dc.citation.endPage | 79 | - |
dc.identifier.bibliographicCitation | TUBERCULOSIS AND RESPIRATORY DISEASES, Vol.87(1) : 65-79, 2024-01 | - |
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