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Preoperative mild cognitive impairment as a risk factor of postoperative cognitive dysfunction in elderly patients undergoing spine surgery
DC Field | Value | Language |
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dc.contributor.author | 구본녀 | - |
dc.contributor.author | 김긍년 | - |
dc.contributor.author | 김정민 | - |
dc.contributor.author | 박수정 | - |
dc.contributor.author | 이성 | - |
dc.contributor.author | 하윤 | - |
dc.date.accessioned | 2024-03-22T06:52:56Z | - |
dc.date.available | 2024-03-22T06:52:56Z | - |
dc.date.issued | 2024-01 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198646 | - |
dc.description.abstract | Introduction: Any persistent degree of cognitive impairment in older adults is a concern as it can progress to dementia. This study aimed to determine the incidence and risk factors for early postoperative cognitive dysfunction (POCD) in elderly patients undergoing spine surgery. Methods: Patients were enrolled from a previous prospective observational study after screening for normal cognitive function using the Mini Mental State Examination (MMSE). Cognitive function was evaluated before surgery and at 1 week, month, and year post-surgery using MMSE and Montreal Cognitive Assessment scores (MoCA). Mild cognitive impairment (MCI) was determined using the MoCA scores adjusted for age. POCD was defined as a drop of three or more points on the MMSE 1 week post-surgery. Multivariate logistic analysis was performed to identify POCD risk factors. Results: A total of 427 patients were included. Eighty-five (20%) had pre-existing MCI. The MCI group showed lower MoCA scores at each time point (baseline, 1 week after surgery, 1 month after surgery, 1 year after surgery) compared to the non-MCI group. Those in the MCI group had a higher rate of admission to intensive care unit after surgery, postoperative delirium, and POCD 1 week post-surgery, than those in the non-MCI group (16.5% vs. 6.7%, p = 0.008; 27.1% vs. 15.8%, p = 0.024; and 18.8% vs. 8.2%, p < 0.001, respectively). Among them, 10.3% were assessed for POCD on postoperative day 7 and self-reported poor social roles and physical functioning 1 week postoperatively. Conclusion: Preoperative MCI was seen in ~20% of surgical patients aged >70 years. POCD was seen in ~20% of patients with pre-existing MCI, and ~ 10% of those without. Benzodiazepine use, significant comorbidities, pre-existing MCI, and depressive tendencies were risk factors for POCD. Copyright © 2024 Park, Kim, Ha, Kim, Yi and Koo. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Frontiers Research Foundation | - |
dc.relation.isPartOf | FRONTIERS IN AGING NEUROSCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Preoperative mild cognitive impairment as a risk factor of postoperative cognitive dysfunction in elderly patients undergoing spine surgery | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) | - |
dc.contributor.googleauthor | Sujung Park | - |
dc.contributor.googleauthor | Jeongmin Kim | - |
dc.contributor.googleauthor | Yoon Ha | - |
dc.contributor.googleauthor | Keung N Kim | - |
dc.contributor.googleauthor | Seong Yi | - |
dc.contributor.googleauthor | Bon-Nyeo Koo | - |
dc.identifier.doi | 10.3389/fnagi.2024.1292942 | - |
dc.contributor.localId | A00193 | - |
dc.contributor.localId | A00331 | - |
dc.contributor.localId | A00884 | - |
dc.contributor.localId | A05707 | - |
dc.contributor.localId | A02864 | - |
dc.contributor.localId | A04255 | - |
dc.relation.journalcode | J00908 | - |
dc.identifier.eissn | 1663-4365 | - |
dc.identifier.pmid | 38282693 | - |
dc.subject.keyword | aged | - |
dc.subject.keyword | cognitive dysfunction | - |
dc.subject.keyword | delirium | - |
dc.subject.keyword | neurocognitive disorders | - |
dc.subject.keyword | perioperative care | - |
dc.subject.keyword | postoperative cognitive complications | - |
dc.contributor.alternativeName | Ku, Bon Nyo | - |
dc.contributor.affiliatedAuthor | 구본녀 | - |
dc.contributor.affiliatedAuthor | 김긍년 | - |
dc.contributor.affiliatedAuthor | 김정민 | - |
dc.contributor.affiliatedAuthor | 박수정 | - |
dc.contributor.affiliatedAuthor | 이성 | - |
dc.contributor.affiliatedAuthor | 하윤 | - |
dc.citation.volume | 16 | - |
dc.citation.startPage | 1292942 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN AGING NEUROSCIENCE, Vol.16 : 1292942, 2024-01 | - |
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