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3'-Sialyllactose alleviates bone loss by regulating bone homeostasis
DC Field | Value | Language |
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dc.contributor.author | 조성래 | - |
dc.date.accessioned | 2024-03-22T06:34:17Z | - |
dc.date.available | 2024-03-22T06:34:17Z | - |
dc.date.issued | 2024-01 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198571 | - |
dc.description.abstract | Osteoporosis is a common skeletal disease that results in an increased risk of fractures. However, there is no definitive cure, warranting the development of potential therapeutic agents. 3'-Sialyllactose (3'-SL) in human milk regulates many biological functions. However, its effect on bone metabolism remains unknown. This study aimed to investigate the molecular mechanisms underlying the effect of 3'-SL on bone homeostasis. Treatment of human bone marrow stromal cells (hBMSCs) with 3'-SL enhanced osteogenic differentiation and inhibited adipogenic differentiation of hBMSCs. RNA sequencing showed that 3'-SL enhanced laminin subunit gamma-2 expression and promoted osteogenic differentiation via the phosphatidylinositol 3‑kinase/protein kinase B signaling pathway. Furthermore, 3'-SL inhibited the receptor activator of nuclear factor κB ligand-induced osteoclast differentiation of bone marrow-derived macrophages through the nuclear factor κB and mitogen‑activated protein kinase signaling pathway, ameliorated osteoporosis in ovariectomized mice, and positively regulated bone remodeling. Our findings suggest 3'-SL as a potential drug for osteoporosis. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group UK | - |
dc.relation.isPartOf | COMMUNICATIONS BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Differentiation / genetics | - |
dc.subject.MESH | Homeostasis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Oligosaccharides* | - |
dc.subject.MESH | Osteogenesis* / genetics | - |
dc.subject.MESH | Osteoporosis* / drug therapy | - |
dc.title | 3'-Sialyllactose alleviates bone loss by regulating bone homeostasis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Rehabilitation Medicine (재활의학교실) | - |
dc.contributor.googleauthor | Ahreum Baek | - |
dc.contributor.googleauthor | Dawoon Baek | - |
dc.contributor.googleauthor | Yoonhee Cho | - |
dc.contributor.googleauthor | Seongmoon Jo | - |
dc.contributor.googleauthor | Jinyoung Kim | - |
dc.contributor.googleauthor | Yoontaik Hong | - |
dc.contributor.googleauthor | Seunghee Cho | - |
dc.contributor.googleauthor | Sung Hoon Kim | - |
dc.contributor.googleauthor | Sung-Rae Cho | - |
dc.identifier.doi | 10.1038/s42003-024-05796-4 | - |
dc.contributor.localId | A03831 | - |
dc.relation.journalcode | J03836 | - |
dc.identifier.eissn | 2399-3642 | - |
dc.identifier.pmid | 38243116 | - |
dc.contributor.alternativeName | Cho, Sung Rae | - |
dc.contributor.affiliatedAuthor | 조성래 | - |
dc.citation.volume | 7 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 110 | - |
dc.identifier.bibliographicCitation | COMMUNICATIONS BIOLOGY, Vol.7(1) : 110, 2024-01 | - |
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