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Association between substantia nigra degeneration and functional outcome in patients with basal ganglia infarction
DC Field | Value | Language |
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dc.contributor.author | 김영대 | - |
dc.contributor.author | 남효석 | - |
dc.contributor.author | 이기정 | - |
dc.contributor.author | 이혜선 | - |
dc.contributor.author | 허지회 | - |
dc.date.accessioned | 2024-03-22T06:31:31Z | - |
dc.date.available | 2024-03-22T06:31:31Z | - |
dc.date.issued | 2024-02 | - |
dc.identifier.issn | 1351-5101 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198567 | - |
dc.description.abstract | Background and purpose: Cerebral infarction in the basal ganglia may cause secondary and delayed neuronal degeneration in the substantia nigra (SN). However, the clinical significance of SN degeneration remains poorly understood. Methods: This retrospective observational study included patients with acute ischemic stroke in the basal ganglia on initial diffusion-weighted imaging who underwent follow-up diffusion-weighted imaging between 4 and 30 days after symptom onset. SN degeneration was defined as a hyperintensity lesion in the SN observed on diffusion-weighted imaging. We compared functional outcomes at 3 months between patients with and without SN degeneration. A poor outcome was defined as a score of 3-6 (functional dependence or death) on the modified Rankin Scale. Results: Of 350 patients with basal ganglia infarction (median age = 74.0 years, 53.7% male), 125 (35.7%) had SN degeneration. The proportion of functional dependence or death was 79.2% (99/125 patients) in patients with SN degeneration, which was significantly higher than that in those without SN degeneration (56.4%, 127/225 patients, p < 0.001). SN degeneration was more frequent in patients with functional dependence or death (99/226 patients, 43.8%) than in those with functional independence (26/124 patients, 21.0%, p < 0.001). Multivariable logistic regression analysis showed a significant association between SN degeneration and functional dependence or death (odds ratio = 2.91, 95% confidence interval = 1.17-7.21, p = 0.021). Conclusions: The study showed that patients with degeneration of SN were associated with functional dependence or death at 3 months, suggesting that secondary degeneration is a predictor of poor stroke outcomes and a potential therapeutic target. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF NEUROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Basal Ganglia / diagnostic imaging | - |
dc.subject.MESH | Basal Ganglia / pathology | - |
dc.subject.MESH | Cerebral Infarction / diagnostic imaging | - |
dc.subject.MESH | Cerebral Infarction / pathology | - |
dc.subject.MESH | Diffusion Magnetic Resonance Imaging | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Ischemic Stroke* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Substantia Nigra / diagnostic imaging | - |
dc.subject.MESH | Substantia Nigra / pathology | - |
dc.title | Association between substantia nigra degeneration and functional outcome in patients with basal ganglia infarction | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Hyungwoo Lee | - |
dc.contributor.googleauthor | Kijeong Lee | - |
dc.contributor.googleauthor | Young Dae Kim | - |
dc.contributor.googleauthor | Hyo Suk Nam | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Sunghee Cho | - |
dc.contributor.googleauthor | Ji Hoe Heo | - |
dc.identifier.doi | 10.1111/ene.16111 | - |
dc.contributor.localId | A00702 | - |
dc.contributor.localId | A01273 | - |
dc.contributor.localId | A02696 | - |
dc.contributor.localId | A03312 | - |
dc.contributor.localId | A04369 | - |
dc.relation.journalcode | J00830 | - |
dc.identifier.eissn | 1468-1331 | - |
dc.identifier.pmid | 37903090 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/ene.16111 | - |
dc.subject.keyword | basal ganglia | - |
dc.subject.keyword | outcome | - |
dc.subject.keyword | prognosis | - |
dc.subject.keyword | secondary degeneration | - |
dc.subject.keyword | substantia nigra | - |
dc.contributor.alternativeName | Kim, Young Dae | - |
dc.contributor.affiliatedAuthor | 김영대 | - |
dc.contributor.affiliatedAuthor | 남효석 | - |
dc.contributor.affiliatedAuthor | 이기정 | - |
dc.contributor.affiliatedAuthor | 이혜선 | - |
dc.contributor.affiliatedAuthor | 허지회 | - |
dc.citation.volume | 31 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | e16111 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF NEUROLOGY, Vol.31(2) : e16111, 2024-02 | - |
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