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Photo-crosslinked gelatin methacryloyl hydrogel strengthened with calcium phosphate-based nanoparticles for early healing of rabbit calvarial defects
DC Field | Value | Language |
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dc.contributor.author | 최성호 | - |
dc.contributor.author | 박진영 | - |
dc.date.accessioned | 2024-02-15T06:59:12Z | - |
dc.date.available | 2024-02-15T06:59:12Z | - |
dc.date.issued | 2023-10 | - |
dc.identifier.issn | 2093-2278 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/198102 | - |
dc.description.abstract | Purpose: The aim of this study was to investigate the efficacy of photo-crosslinked gelatin methacryloyl (GelMa) hydrogel containing calcium phosphate nanoparticles (CNp) when applying different fabrication methods for bone regeneration. Methods: Four circular defects were created in the calvaria of 10 rabbits. Each defect was randomly allocated to the following study groups: 1) the sham control group, 2) the GelMa group (defect filled with crosslinked GelMa hydrogel), 3) the CNp-GelMa group (GelMa hydrogel crosslinked with nanoparticles), and 4) the CNp+GelMa group (crosslinked GelMa loaded with nanoparticles). At 2, 4, and 8 weeks, samples were harvested, and histological and micro-computed tomography analyses were performed. Results: Histomorphometric analysis showed that the CNp-GelMa and CNp+GelMa groups at 2 weeks had significantly greater total augmented areas than the control group (P<0.05). The greatest new bone area was observed in the CNp-GelMa group, but without statistical significance (P>0.05). Crosslinked GelMa hydrogel with nanoparticles exhibited good biocompatibility with a minimal inflammatory reaction. Conclusions: There was no difference in the efficacy of bone regeneration according to the synthesized method of photo-crosslinked GelMa hydrogel with nanoparticles. However, these materials could remain within a bone defect up to 2 weeks and showed good biocompatibility with little inflammatory response. Further improvement in mechanical properties and resistance to enzymatic degradation would be needed for the clinical application. © 2023. Korean Academy of Periodontology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/). All Rights Reserved. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Korean Academy of Periodontology | - |
dc.relation.isPartOf | JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Photo-crosslinked gelatin methacryloyl hydrogel strengthened with calcium phosphate-based nanoparticles for early healing of rabbit calvarial defects | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Periodontics (치주과학교실) | - |
dc.contributor.googleauthor | Da-Na Lee | - |
dc.contributor.googleauthor | Jin-Young Park | - |
dc.contributor.googleauthor | Young-Wook Seo | - |
dc.contributor.googleauthor | Xiang Jin | - |
dc.contributor.googleauthor | Jongmin Hong | - |
dc.contributor.googleauthor | Amitava Bhattacharyya | - |
dc.contributor.googleauthor | Insup Noh | - |
dc.contributor.googleauthor | Seong-Ho Choi | - |
dc.identifier.doi | 10.5051/jpis.2203220161 | - |
dc.contributor.localId | A04081 | - |
dc.relation.journalcode | J01695 | - |
dc.identifier.eissn | 2093-2286 | - |
dc.identifier.pmid | 36919004 | - |
dc.subject.keyword | Animals | - |
dc.subject.keyword | Biomaterials | - |
dc.subject.keyword | Bone regeneration | - |
dc.subject.keyword | Gelatin methacryloyl | - |
dc.subject.keyword | Nanoparticles | - |
dc.contributor.alternativeName | Choi, Seong Ho | - |
dc.contributor.affiliatedAuthor | 최성호 | - |
dc.citation.volume | 53 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 321 | - |
dc.citation.endPage | 335 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE, Vol.53(5) : 321-335, 2023-10 | - |
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