Cited 1 times in
Postchemoradiation magnetic resonance imaging circumferential resection margin predicts treatment failure after multidisciplinary directed sphincter preservation in low rectal cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 민병소 | - |
dc.contributor.author | 양승윤 | - |
dc.contributor.author | 이강영 | - |
dc.contributor.author | 이용준 | - |
dc.contributor.author | 임준석 | - |
dc.contributor.author | 조민수 | - |
dc.contributor.author | 한윤대 | - |
dc.contributor.author | 허혁 | - |
dc.contributor.author | 김선정 | - |
dc.date.accessioned | 2024-02-15T06:41:43Z | - |
dc.date.available | 2024-02-15T06:41:43Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.issn | 0022-4790 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197997 | - |
dc.description.abstract | Background: This study aimed to review the magnetic resonance imaging (MRI) features of patients with low rectal cancer (LRC) undergoing preoperative chemoradiotherapy (CRT) and investigate the risk factors for treatment failure after sphincter preserving surgery following preoperative CRT based on multidisciplinary approach.Objectives: Patients who underwent standard CRT and sphincter preserving radical surgery for LRC between January 2000 and December 2011 were retrospectively reviewed. Sphincter preservation failure (SPF) was defined as any one of the following: positive pathologic circumferential resection margin, local recurrence, failure to repair ileostomy, or permanent stoma formation due to anastomotic complications.Results: Among the 191 patients, there were no overall significant differences between sphincter preservation success (n = 161) and SPF (n = 30) groups. SPF group showed a higher MRI circumferential resection margins (mrCRM) positive rate before and after CRT (before CRT: 33.3% vs. 16.1%, p = 0.027; after CRT: 23.3% vs. 6.2%, p = 0.002). Multivariate analysis showed that only mrCRM after CRT was associated with SPF (hazard ratio = 4.596, p = 0.005). SPF group showed worse 5-year cancer-specific survival (51% vs. 92.7%, p < 0.001).Conclusions: MRI-based assessment of the tumor after CRT plays a crucial role in predicting the success and feasibility of sphincter preservation as well as oncological outcomes in patients with LRC. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Liss | - |
dc.relation.isPartOf | JOURNAL OF SURGICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Chemoradiotherapy / methods | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Margins of Excision* | - |
dc.subject.MESH | Neoadjuvant Therapy / methods | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Rectal Neoplasms* / diagnostic imaging | - |
dc.subject.MESH | Rectal Neoplasms* / surgery | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Treatment Failure | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Postchemoradiation magnetic resonance imaging circumferential resection margin predicts treatment failure after multidisciplinary directed sphincter preservation in low rectal cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Sun Jung Kim | - |
dc.contributor.googleauthor | Yong Joon Lee | - |
dc.contributor.googleauthor | Min Young Park | - |
dc.contributor.googleauthor | Seung Yoon Yang | - |
dc.contributor.googleauthor | Yoon Dae Han | - |
dc.contributor.googleauthor | Min Soo Cho | - |
dc.contributor.googleauthor | Hyuk Hur | - |
dc.contributor.googleauthor | Kang Young Lee | - |
dc.contributor.googleauthor | Joon Seok Lim | - |
dc.contributor.googleauthor | Byung Soh Min | - |
dc.identifier.doi | 10.1002/jso.27449 | - |
dc.contributor.localId | A01402 | - |
dc.contributor.localId | A05359 | - |
dc.contributor.localId | A02640 | - |
dc.contributor.localId | A06392 | - |
dc.contributor.localId | A03408 | - |
dc.contributor.localId | A03817 | - |
dc.contributor.localId | A04313 | - |
dc.contributor.localId | A04373 | - |
dc.relation.journalcode | J01762 | - |
dc.identifier.eissn | 1096-9098 | - |
dc.identifier.pmid | 37732720 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/jso.27449 | - |
dc.subject.keyword | circumferential resection margins | - |
dc.subject.keyword | magnetic resonance imaging | - |
dc.subject.keyword | neoadjuvant chemoradiotherapy | - |
dc.subject.keyword | rectal cancer | - |
dc.subject.keyword | sphincter preservation failure | - |
dc.contributor.alternativeName | Min, Byung Soh | - |
dc.contributor.affiliatedAuthor | 민병소 | - |
dc.contributor.affiliatedAuthor | 양승윤 | - |
dc.contributor.affiliatedAuthor | 이강영 | - |
dc.contributor.affiliatedAuthor | 이용준 | - |
dc.contributor.affiliatedAuthor | 임준석 | - |
dc.contributor.affiliatedAuthor | 조민수 | - |
dc.contributor.affiliatedAuthor | 한윤대 | - |
dc.contributor.affiliatedAuthor | 허혁 | - |
dc.citation.volume | 128 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1365 | - |
dc.citation.endPage | 1371 | - |
dc.identifier.bibliographicCitation | JOURNAL OF SURGICAL ONCOLOGY, Vol.128(8) : 1365-1371, 2023-12 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.