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Diagnosis of Eosinophilic Otitis Media Using Blood Eosinophil Levels

Authors
 Yeonsu Jeong  ;  Gina Na  ;  Jong-Gyun Ha  ;  Dachan Kim  ;  Junyup Kim  ;  Seonghoon Bae 
Citation
 DIAGNOSTICS, Vol.13(23) : 3598, 2023-12 
Journal Title
DIAGNOSTICS
Issue Date
2023-12
Keywords
chronic rhinosinusitis ; eosinophilic otitis media ; eosinophils ; granulomatosis with polyangiitis ; primary ciliary dyskinesia
Abstract
Eosinophilic otitis media (EOM) is a rare middle ear disease with unfavorable outcomes. Under the current diagnostic criteria of EOM, it is challenging to suspect EOM before tympanostomy. Therefore, this study attempted to use blood eosinophil levels for the differential diagnosis of EOM from other conditions. Three disease groups with features of recurrent otorrhea were categorized, which included the following: EOM (n = 9), granulomatosis with polyangiitis (GPA, n = 12), and primary ciliary dyskinesia (PCD, n = 6). Clinical and radiological characteristics were analyzed in the three groups. Patients who underwent ventilation tube insertion due to serous otitis media were enrolled as the control group (n = 225) to evaluate the diagnostic validity of blood eosinophilia. The EOM group showed a significantly higher blood eosinophil concentration (p < 0.001) and blood eosinophil count (p < 0.001) compared to the GPA and PCD groups. The estimated sensitivity and specificity for diagnosing EOM from OME patients who underwent ventilation tube insertion were 100% and 95.6%, respectively. In addition, EOM tended to have protympanic space soft tissue density and a relatively clear retrotympanic space in temporal bone computerized tomography. Blood eosinophil evaluation is a significant clinical indicator of EOM. Furthermore, the assessment of exclusive protympanic soft tissue density can provide an additional diagnostic clue. © 2023 by the authors.
Files in This Item:
T202400681.pdf Download
DOI
10.3390/diagnostics13233598
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Na, Gina(나지나)
Bae, Seong Hoon(배성훈) ORCID logo https://orcid.org/0000-0001-9243-9392
Jeong, Yeonsu(정연수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/197961
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