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Cross-Activation of Regulatory T Cells by Self Antigens Limits Self-Reactive and Activated CD8+ T Cell Responses
DC Field | Value | Language |
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dc.contributor.author | 남기택 | - |
dc.date.accessioned | 2024-01-03T00:52:09Z | - |
dc.date.available | 2024-01-03T00:52:09Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197396 | - |
dc.description.abstract | The interaction between regulatory T (Treg) cells and self-reactive T cells is a crucial mechanism for maintaining immune tolerance. In this study, we investigated the cross-activation of Treg cells by self-antigens and its impact on self-reactive CD8+ T cell responses, with a focus on the P53 signaling pathway. We discovered that major histocompatibility complex (MHC) I-restricted self-peptides not only activated CD8+ T cells but also induced the delayed proliferation of Treg cells. Following HLA-A*0201-restricted Melan-A-specific (pMelan) CD8+ T cells, we observed the direct expansion of Treg cells and concurrent suppression of pMelan+CD8+ T cell proliferation upon stimulation with Melan-A peptide. Transcriptome analysis revealed no significant alterations in specific signaling pathways in pMelan+CD8+ T cells that were co-cultured with activated Treg cells. However, there was a noticeable upregulation of genes involved in P53 accumulation, a critical regulator of cell survival and apoptosis. Consistent with such observation, the blockade of P53 induced a continuous proliferation of pMelan+CD8+ T cells. The concurrent stimulation of Treg cells through self-reactive TCRs by self-antigens provides insights into the immune system's ability to control activated self-reactive CD8+ T cells as part of peripheral tolerance, highlighting the intricate interplay between Treg cells and CD8+ T cells and implicating therapeutic interventions in autoimmune diseases and cancer immunotherapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Autoantigens / metabolism | - |
dc.subject.MESH | CD8 Antigens / metabolism | - |
dc.subject.MESH | CD8-Positive T-Lymphocytes* | - |
dc.subject.MESH | Histocompatibility Antigens / metabolism | - |
dc.subject.MESH | MART-1 Antigen / metabolism | - |
dc.subject.MESH | T-Lymphocytes, Regulatory* | - |
dc.subject.MESH | Tumor Suppressor Protein p53 / metabolism | - |
dc.title | Cross-Activation of Regulatory T Cells by Self Antigens Limits Self-Reactive and Activated CD8+ T Cell Responses | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | BioMedical Science Institute (의생명과학부) | - |
dc.contributor.googleauthor | Eunjung Cho | - |
dc.contributor.googleauthor | Seongeun Han | - |
dc.contributor.googleauthor | Hyeon Seok Eom | - |
dc.contributor.googleauthor | Sang-Jin Lee | - |
dc.contributor.googleauthor | Chungyong Han | - |
dc.contributor.googleauthor | Rohit Singh | - |
dc.contributor.googleauthor | Seon-Hee Kim | - |
dc.contributor.googleauthor | Bo-Mi Park | - |
dc.contributor.googleauthor | Byoung-Gie Kim | - |
dc.contributor.googleauthor | Young H Kim | - |
dc.contributor.googleauthor | Byoung S Kwon | - |
dc.contributor.googleauthor | Ki Taek Nam | - |
dc.contributor.googleauthor | Beom K Choi | - |
dc.identifier.doi | 10.3390/ijms241813672 | - |
dc.contributor.localId | A01243 | - |
dc.relation.journalcode | J01133 | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.pmid | 37761976 | - |
dc.subject.keyword | CD8+ T cell | - |
dc.subject.keyword | p53 | - |
dc.subject.keyword | peripheral tolerance | - |
dc.subject.keyword | regulatory T cells | - |
dc.subject.keyword | self-antigen | - |
dc.contributor.alternativeName | Nam, Ki Taek | - |
dc.contributor.affiliatedAuthor | 남기택 | - |
dc.citation.volume | 24 | - |
dc.citation.number | 18 | - |
dc.citation.startPage | 13672 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.24(18) : 13672, 2023-09 | - |
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