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Silibinin Downregulates Types I and III Collagen Expression via Suppression of the mTOR Signaling Pathway
DC Field | Value | Language |
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dc.contributor.author | 김지희 | - |
dc.contributor.author | 이영인 | - |
dc.contributor.author | 이원재 | - |
dc.contributor.author | 이주희 | - |
dc.date.accessioned | 2024-01-03T00:51:57Z | - |
dc.date.available | 2024-01-03T00:51:57Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197394 | - |
dc.description.abstract | Keloid scars are fibro-proliferative conditions characterized by abnormal fibroblast proliferation and excessive extracellular matrix deposition. The mammalian target of the rapamycin (mTOR) pathway has emerged as a potential therapeutic target in keloid disease. Silibinin, a natural flavonoid isolated from the seeds and fruits of the milk thistle, is known to inhibit the mTOR signaling pathway in human cervical and hepatoma cancer cells. However, the mechanisms underlying this inhibitory effect are not fully understood. This in vitro study investigated the effects of silibinin on collagen expression in normal human dermal and keloid-derived fibroblasts. We evaluated the effects of silibinin on the expressions of collagen types I and III and assessed its effects on the suppression of the mTOR signaling pathway. Our findings confirmed elevated mTOR phosphorylation levels in keloid scars compared to normal tissue specimens. Silibinin treatment significantly reduced collagen I and III expressions in normal human dermal and keloid-derived fibroblasts. These effects were accompanied by the suppression of the mTOR signaling pathway. Our findings suggest the potential of silibinin as a promising therapeutic agent for preventing and treating keloid scars. Further studies are warranted to explore the clinical application of silibinin in scar management. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Collagen | - |
dc.subject.MESH | Collagen Type I / genetics | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Keloid* | - |
dc.subject.MESH | Mammals | - |
dc.subject.MESH | Signal Transduction | - |
dc.subject.MESH | Silybin / pharmacology | - |
dc.subject.MESH | TOR Serine-Threonine Kinases | - |
dc.title | Silibinin Downregulates Types I and III Collagen Expression via Suppression of the mTOR Signaling Pathway | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학교실) | - |
dc.contributor.googleauthor | Sooyeon Choi | - |
dc.contributor.googleauthor | Seoyoon Ham | - |
dc.contributor.googleauthor | Young In Lee | - |
dc.contributor.googleauthor | Jihee Kim | - |
dc.contributor.googleauthor | Won Jai Lee | - |
dc.contributor.googleauthor | Ju Hee Lee | - |
dc.identifier.doi | 10.3390/ijms241814386 | - |
dc.contributor.localId | A04732 | - |
dc.contributor.localId | A05880 | - |
dc.contributor.localId | A03005 | - |
dc.contributor.localId | A03171 | - |
dc.relation.journalcode | J01133 | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.pmid | 37762688 | - |
dc.subject.keyword | fibrosis | - |
dc.subject.keyword | flavonoid | - |
dc.subject.keyword | keloid scar | - |
dc.subject.keyword | mammalian target of rapamycin (mTOR) | - |
dc.subject.keyword | natural compound | - |
dc.subject.keyword | silibinin | - |
dc.contributor.alternativeName | Kim, Jihee | - |
dc.contributor.affiliatedAuthor | 김지희 | - |
dc.contributor.affiliatedAuthor | 이영인 | - |
dc.contributor.affiliatedAuthor | 이원재 | - |
dc.contributor.affiliatedAuthor | 이주희 | - |
dc.citation.volume | 24 | - |
dc.citation.number | 18 | - |
dc.citation.startPage | 14386 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.24(18) : 14386, 2023-09 | - |
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