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Inhibiting the cytosolic function of CXXC5 accelerates diabetic wound healing by enhancing angiogenesis and skin repair
DC Field | Value | Language |
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dc.contributor.author | 박광환 | - |
dc.contributor.author | 이경미 | - |
dc.contributor.author | 이진우 | - |
dc.date.accessioned | 2024-01-03T00:39:47Z | - |
dc.date.available | 2024-01-03T00:39:47Z | - |
dc.date.issued | 2023-08 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197329 | - |
dc.description.abstract | Diabetic wound healing, including diabetic foot ulcer (DFU), is a serious complication of diabetes. Considering the complexity of DFU development, the identification of a factor that mediates multiple pathogeneses is important for treatment. In this study, we found that CXXC-type zinc finger protein 5 (CXXC5), a negative regulator of the Wnt/β-catenin pathway, was overexpressed with suppression of the Wnt/β-catenin pathway and its target genes involved in wound healing and angiogenesis in the wound tissues of DFU patients and diabetes-induced model mice. KY19334, a small molecule that activates the Wnt/β-catenin pathway by inhibiting the CXXC5-Dvl interaction, accelerated wound healing in diabetic mice. The enhancement of diabetic wound healing could be achieved by restoring the suppressed Wnt/β-catenin signaling and subsequently inducing its target genes. Moreover, KY19334 induced angiogenesis in hindlimb ischemia model mice. Overall, these findings revealed that restorative activation of Wnt/β-catenin signaling by inhibiting the function of cytosolic CXXC5 could be a therapeutic approach for treating DFUs. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | DNA-Binding Proteins / genetics | - |
dc.subject.MESH | DNA-Binding Proteins / metabolism | - |
dc.subject.MESH | Diabetes Mellitus, Experimental* / complications | - |
dc.subject.MESH | Diabetic Foot* / metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Transcription Factors / genetics | - |
dc.subject.MESH | Wnt Signaling Pathway / physiology | - |
dc.subject.MESH | Wound Healing* / physiology | - |
dc.subject.MESH | beta Catenin / metabolism | - |
dc.title | Inhibiting the cytosolic function of CXXC5 accelerates diabetic wound healing by enhancing angiogenesis and skin repair | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Orthopedic Surgery (정형외과학교실) | - |
dc.contributor.googleauthor | Eunhwan Kim | - |
dc.contributor.googleauthor | Seol Hwa Seo | - |
dc.contributor.googleauthor | Yumi Hwang | - |
dc.contributor.googleauthor | Yeong Chan Ryu | - |
dc.contributor.googleauthor | Heejene Kim | - |
dc.contributor.googleauthor | Kyoung-Mi Lee | - |
dc.contributor.googleauthor | Jin Woo Lee | - |
dc.contributor.googleauthor | Kwang Hwan Park | - |
dc.contributor.googleauthor | Kang-Yell Choi | - |
dc.identifier.doi | 10.1038/s12276-023-01064-3 | - |
dc.contributor.localId | A01437 | - |
dc.contributor.localId | A04619 | - |
dc.contributor.localId | A03230 | - |
dc.relation.journalcode | J00860 | - |
dc.identifier.eissn | 2092-6413 | - |
dc.identifier.pmid | 37524876 | - |
dc.contributor.alternativeName | Park, Kwang Hwan | - |
dc.contributor.affiliatedAuthor | 박광환 | - |
dc.contributor.affiliatedAuthor | 이경미 | - |
dc.contributor.affiliatedAuthor | 이진우 | - |
dc.citation.volume | 55 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1770 | - |
dc.citation.endPage | 1782 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, Vol.55(8) : 1770-1782, 2023-08 | - |
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