Cited 0 times in
Nectin-4 as a Predictive Marker for Poor Prognosis of Endometrial Cancer with Mismatch Repair Impairment
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김재훈 | - |
dc.contributor.author | 조한별 | - |
dc.contributor.author | 최정아 | - |
dc.contributor.author | 김효선 | - |
dc.date.accessioned | 2024-01-03T00:26:26Z | - |
dc.date.available | 2024-01-03T00:26:26Z | - |
dc.date.issued | 2023-05 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197265 | - |
dc.description.abstract | The adhesion molecule Nectin-4 is a new potential therapeutic target for different types of cancer; however, little is known about its diagnosis significance in endometrial cancer (EC). We found that Nectin-4 expression was significantly higher in EC tissues than in nonadjacent normal tissue. The area under the receiver operating characteristic curve value of 0.922 indicated good diagnostic accuracy for Nectin-4 expression in EC. Furthermore, Nectin-4 expression was associated with DNA mismatch repair (MMR) protein deficiency. Notably, the high Nectin-4 expression group of patients with MSH2/6-deficient EC had shorter progression-free survival than that of the low Nectin-4 expression group. The number of lymphovascular space invasion-positive patients in groups with MMR deficiency and high Nectin-4 expression was also increased compared with that in the low Nectin-4 expression group. Bioinformatics analysis revealed that alteration in Nectin-4 and MMR genes is associated with Nectin-4 expression in EC. To the best of our knowledge, this is the first study to show that Nectin-4 expression may be a potential biomarker for EC diagnosis and that high Nectin-4 expression in MMR-deficient patients with EC can predict short progression-free survival, thus providing clues to identify patients for adjuvant therapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | CANCERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Nectin-4 as a Predictive Marker for Poor Prognosis of Endometrial Cancer with Mismatch Repair Impairment | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics and Gynecology (산부인과학교실) | - |
dc.contributor.googleauthor | Ha Kyun Chang | - |
dc.contributor.googleauthor | Young Hoon Park | - |
dc.contributor.googleauthor | Jung-A Choi | - |
dc.contributor.googleauthor | Jeong Won Kim | - |
dc.contributor.googleauthor | Jisup Kim | - |
dc.contributor.googleauthor | Hyo Sun Kim | - |
dc.contributor.googleauthor | Hae Nam Lee | - |
dc.contributor.googleauthor | Hanbyoul Cho | - |
dc.contributor.googleauthor | Joon-Yong Chung | - |
dc.contributor.googleauthor | Jae-Hoon Kim | - |
dc.identifier.doi | 10.3390/cancers15102865 | - |
dc.contributor.localId | A00876 | - |
dc.contributor.localId | A03921 | - |
dc.contributor.localId | A05860 | - |
dc.relation.journalcode | J03449 | - |
dc.identifier.eissn | 2072-6694 | - |
dc.identifier.pmid | 37345201 | - |
dc.subject.keyword | MSH2 | - |
dc.subject.keyword | MSH6 | - |
dc.subject.keyword | Nectin-4 | - |
dc.subject.keyword | endometrial cancer | - |
dc.contributor.alternativeName | Kim, Jae Hoon | - |
dc.contributor.affiliatedAuthor | 김재훈 | - |
dc.contributor.affiliatedAuthor | 조한별 | - |
dc.contributor.affiliatedAuthor | 최정아 | - |
dc.citation.volume | 15 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2865 | - |
dc.identifier.bibliographicCitation | CANCERS, Vol.15(10) : 2865, 2023-05 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.