Cited 2 times in
Validating lactate dehydrogenase (LDH) as a component of the PLASMIC predictive tool (PLASMIC-LDH)
DC Field | Value | Language |
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dc.contributor.author | 김진석 | - |
dc.date.accessioned | 2024-01-03T00:19:03Z | - |
dc.date.available | 2024-01-03T00:19:03Z | - |
dc.date.issued | 2023-03 | - |
dc.identifier.issn | 2287-979X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/197228 | - |
dc.description.abstract | Background: The PLASMIC score is a convenient tool for predicting ADAMTS13 activity of <10%. Lactate dehydrogenase (LDH) is widely used as a marker of haemolysis in thrombotic thrombocytopenic purpura (TTP) monitoring, and could be used as a replacement marker for lysis. We aimed to validate the PLASMIC score in a multi-centre Asia Pacific region, and to explore whether LDH could be used as a replacement marker for lysis. Methods: Records of patients with thrombotic microangiopathy (TMA) were reviewed. Patients' ADAMTS13 activity levels were obtained, along with clinical/laboratory findings relevant to the PLASMIC score. Both PLASMIC scores and PLASMIC-LDH scores, in which LDH replaced traditional lysis markers, were calculated. We generated a receiver operator characteristics (ROC) curve and compared the area under the curve values (AUC) to determine the predictive ability of each score. Results: 46 patients fulfilled the inclusion criteria, of which 34 had ADAMTS13 activity levels of <10%. When the patients were divided into intermediate-to-high risk (scores 5‒7) and low risk (scores 0‒4), the PLASMIC score showed a sensitivity of 97.1% and specificity of 58.3%, with a positive predictive value (PPV) of 86.8% and negative predictive value (NPV) of 87.5%. The PLASMIC-LDH score had a sensitivity of 97.1% and specificity of 33.3%, with a PPV of 80.5% and NPV of 80.0%. Conclusion: Our study validated the utility of the PLASMIC score, and demonstrated PLASMIC-LDH as a reasonable alternative in the absence of traditional lysis markers, to help identify high-risk patients for treatment via plasma exchange. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korea Society of Hematology | - |
dc.relation.isPartOf | BLOOD RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Validating lactate dehydrogenase (LDH) as a component of the PLASMIC predictive tool (PLASMIC-LDH) | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Christopher Chin Keong Liam | - |
dc.contributor.googleauthor | Jim Yu-Hsiang Tiao | - |
dc.contributor.googleauthor | Yee Yee Yap | - |
dc.contributor.googleauthor | Yi Lin Lee | - |
dc.contributor.googleauthor | Jameela Sathar | - |
dc.contributor.googleauthor | Simon McRae | - |
dc.contributor.googleauthor | Amanda Davis | - |
dc.contributor.googleauthor | Jennifer Curnow | - |
dc.contributor.googleauthor | Robert Bird | - |
dc.contributor.googleauthor | Philip Choi | - |
dc.contributor.googleauthor | Pantep Angchaisuksiri | - |
dc.contributor.googleauthor | Sim Leng Tien | - |
dc.contributor.googleauthor | Joyce Ching Mei Lam | - |
dc.contributor.googleauthor | Doyeun Oh | - |
dc.contributor.googleauthor | Jin Seok Kim | - |
dc.contributor.googleauthor | Sung-Soo Yoon | - |
dc.contributor.googleauthor | Raymond Siu-Ming Wong | - |
dc.contributor.googleauthor | Carolyn Lauren | - |
dc.contributor.googleauthor | Eileen Grace Merriman | - |
dc.contributor.googleauthor | Anoop Enjeti | - |
dc.contributor.googleauthor | Mark Smith | - |
dc.contributor.googleauthor | Ross Ian Baker | - |
dc.identifier.doi | 10.5045/br.2023.2022133 | - |
dc.contributor.localId | A01017 | - |
dc.relation.journalcode | J00346 | - |
dc.identifier.eissn | 2288-0011 | - |
dc.identifier.pmid | 36632683 | - |
dc.subject.keyword | Lactate dehydrogenase (LDH) | - |
dc.subject.keyword | PLASMIC score | - |
dc.subject.keyword | Thrombotic microangiopathy | - |
dc.contributor.alternativeName | Kim, Jin Seok | - |
dc.contributor.affiliatedAuthor | 김진석 | - |
dc.citation.volume | 58 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 36 | - |
dc.citation.endPage | 41 | - |
dc.identifier.bibliographicCitation | BLOOD RESEARCH, Vol.58(1) : 36-41, 2023-03 | - |
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