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Association between Low Blood Pressure and Subsequent Risk of Parkinson's Disease in Older Adults Aged ≥75 Years
DC Field | Value | Language |
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dc.contributor.author | 김용욱 | - |
dc.contributor.author | 신재용 | - |
dc.contributor.author | 윤서연 | - |
dc.contributor.author | 이상철 | - |
dc.date.accessioned | 2023-11-28T03:23:41Z | - |
dc.date.available | 2023-11-28T03:23:41Z | - |
dc.date.issued | 2023-11 | - |
dc.identifier.issn | 0304-324X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196795 | - |
dc.description.abstract | Introduction: The association between blood pressure (BP) and incidence of Parkinson's disease (PD) in older adults remains uncertain. Therefore, this study aimed to investigate the association between BP (high or low) and PD incidence in adults aged ≥75 years. Methods: In this nationwide population-based cohort study, we enrolled participants aged ≥75 years without a prior PD diagnosis who had undergone health examination provided by the Korean National Health Insurance Service at least once from January 1, 2009, to December 31, 2012. The participants were followed up until December 31, 2019, or the date of their death. The Cox proportional hazards model was used to assess the risk of PD depending on systolic BP (SBP), diastolic BP (DBP), and pulse pressure. Results: Overall, 963,525 participants were enrolled in the analysis and followed up until December 31, 2019, or the date of death (40.7% male, mean age 78.5 ± 3.6 years). The mean SBP and DBP were 131.4 ± 16.7 and 77.9 ± 10.3 mm Hg, respectively. During the 10-year follow-up period, 16,414 (1.7%) newly diagnosed cases of PD were reported. A significant inverse dose-response association was found between SBP and PD incidence. In the subgroup analysis, this association was maintained for most variables, including sex, use of antihypertensive medication, comorbidities, alcohol consumption, physical activity, and body mass index, except for smoking status. Conclusion: Lower SBP and DBP were associated with a higher PD incidence in older adults. These results may have substantial implications for determining the optimal BP control target in adults aged ≥75 years. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Karger | - |
dc.relation.isPartOf | GERONTOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Blood Pressure / physiology | - |
dc.subject.MESH | Cardiovascular Diseases* / epidemiology | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertension* / complications | - |
dc.subject.MESH | Hypertension* / epidemiology | - |
dc.subject.MESH | Hypotension* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Parkinson Disease* / complications | - |
dc.subject.MESH | Parkinson Disease* / etiology | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Association between Low Blood Pressure and Subsequent Risk of Parkinson's Disease in Older Adults Aged ≥75 Years | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Rehabilitation Medicine (재활의학교실) | - |
dc.contributor.googleauthor | Ja Young Choi | - |
dc.contributor.googleauthor | Kyungdo Han | - |
dc.contributor.googleauthor | Yong Wook Kim | - |
dc.contributor.googleauthor | Sang Chul Lee | - |
dc.contributor.googleauthor | Jaeyong Shin | - |
dc.contributor.googleauthor | Seung Nam Yang | - |
dc.contributor.googleauthor | Seo Yeon Yoon | - |
dc.identifier.doi | 10.1159/000533676 | - |
dc.contributor.localId | A00750 | - |
dc.contributor.localId | A02140 | - |
dc.contributor.localId | A02562 | - |
dc.contributor.localId | A02832 | - |
dc.relation.journalcode | J00945 | - |
dc.identifier.eissn | 1423-0003 | - |
dc.identifier.pmid | 37640013 | - |
dc.identifier.url | https://karger.com/ger/article/69/11/1269/862104/Association-between-Low-Blood-Pressure-and | - |
dc.subject.keyword | Blood pressure | - |
dc.subject.keyword | Epidemiology | - |
dc.subject.keyword | Hypertension | - |
dc.subject.keyword | Older adults | - |
dc.subject.keyword | Parkinson’s disease | - |
dc.contributor.alternativeName | Kim, Yong Wook | - |
dc.contributor.affiliatedAuthor | 김용욱 | - |
dc.contributor.affiliatedAuthor | 신재용 | - |
dc.contributor.affiliatedAuthor | 윤서연 | - |
dc.contributor.affiliatedAuthor | 이상철 | - |
dc.citation.volume | 69 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1269 | - |
dc.citation.endPage | 1277 | - |
dc.identifier.bibliographicCitation | GERONTOLOGY, Vol.69(11) : 1269-1277, 2023-11 | - |
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