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Long-term efficacy and safety of adjunctive perampanel in pediatric patients aged 4-19 years with epilepsy: a real-world study
DC Field | Value | Language |
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dc.contributor.author | 강훈철 | - |
dc.contributor.author | 김세희 | - |
dc.contributor.author | 김흥동 | - |
dc.contributor.author | 이준수 | - |
dc.contributor.author | 윤송이 | - |
dc.date.accessioned | 2023-11-07T07:47:04Z | - |
dc.date.available | 2023-11-07T07:47:04Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196514 | - |
dc.description.abstract | This study determined the 24-month outcomes of perampanel treatment in children and adolescents with epilepsy. The percentage of ≥ 50% responders was 47.3% (139/294) at 12 months and 49.0% (144/294) at 24 months. A 100% reduction in seizures for more than 12 months was observed in 12.2% (36/294). Discontinuation occurred in 39.8% (117/294). The most common reason for discontinuation was adverse events (29.1%, 34/117). Baseline seizure frequency was higher in children aged < 12 years than in patients aged ≥ 12 years; however, the percentage of seizure reduction and ≥ 50% responders did not significantly differ between the two groups. The rate of early discontinuation was higher (p < 0.001) and the duration of perampanel treatment was shorter in children aged < 12 years (p = 0.001). Most children aged < 12 years discontinued PER due to inadequate effectiveness, while adverse event was the most common reason in patients aged ≥ 12 years (p = 0.045). Only slow titration was significantly associated with ≥ 50% of responders. In conclusion, this study showed that perampanel can be utilized effectively and safely for a prolonged period in pediatric patients aged 4 to < 12 years, as well as in patients aged 12 years and older. © 2023. Springer Nature Limited. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Dental Care | - |
dc.subject.MESH | Epilepsy* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Pyridones | - |
dc.subject.MESH | Seizures | - |
dc.title | Long-term efficacy and safety of adjunctive perampanel in pediatric patients aged 4-19 years with epilepsy: a real-world study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | Song Ee Youn | - |
dc.contributor.googleauthor | Hoon-Chul Kang | - |
dc.contributor.googleauthor | Joon Soo Lee | - |
dc.contributor.googleauthor | Heung Dong Kim | - |
dc.contributor.googleauthor | Se Hee Kim | - |
dc.identifier.doi | 10.1038/s41598-023-40594-8 | - |
dc.contributor.localId | A00102 | - |
dc.contributor.localId | A00611 | - |
dc.contributor.localId | A01208 | - |
dc.contributor.localId | A03177 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 37658098 | - |
dc.contributor.alternativeName | Kang, Hoon Chul | - |
dc.contributor.affiliatedAuthor | 강훈철 | - |
dc.contributor.affiliatedAuthor | 김세희 | - |
dc.contributor.affiliatedAuthor | 김흥동 | - |
dc.contributor.affiliatedAuthor | 이준수 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 14369 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.13(1) : 14369, 2023-12 | - |
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