Cited 5 times in
Outcomes of non-ischaemic coronary lesions with high-risk plaque characteristics on coronary CT angiography
DC Field | Value | Language |
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dc.contributor.author | 장혁재 | - |
dc.date.accessioned | 2023-10-19T06:11:09Z | - |
dc.date.available | 2023-10-19T06:11:09Z | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 1774-024X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196381 | - |
dc.description.abstract | Background: The integrative implications of quantitative and qualitative plaque characteristics on clinical outcomes and therapeutic guidance have not been fully investigated. Aims: We aimed to investigate the combined prognostic value of quantitative and qualitative plaque measures and their interactions with treatment modalities and physiological lesion severity. Methods: Among 697 vessels from 458 patients who underwent fractional flow reserve (FFR)-guided treatment, quantitative high-risk plaque (qn-HRP; plaque burden ≥70% and minimum lumen area <3.3 mm2) and qualitative HRP (ql-HRP; low-attenuation plaque or positive remodelling) were defined on coronary computed tomography angiography (CCTA). The primary endpoint was the vessel-oriented composite outcome (VOCO; a composite of cardiac death, myocardial infarction, or revascularisation). Results: The mean baseline FFR was 0.85±0.12, and 25.8% underwent percutaneous coronary intervention (PCI) during the index procedure. In medically treated lesions, both qn-HRP and ql-HRP were associated with an increased risk of VOCO (p<0.05). Relative to the lesions with qn-HRP(-)/ql-HRP(-),those with qn-HRP(+)/ql-HRP(+) showed a higher risk of VOCO (hazard ratio [HR] 8.36, 95% confidence interval [CI]: 2.86-24.44). The PCI group showed a lower risk for VOCO than the medical treatment group (HR 0.31, 95% CI: 0.11-0.91) in lesions with qn-HRP(+)/ql-HRP(+). This difference was consistent in lesions with an FFR of 0.81-0.90 (HR 0.19, 95 CI: 0.04-0.90), but not in those with an FFR of>0.90. Conclusions: In non-ischaemic lesions, ql-HRP and qn-HRP showed a synergistic impact on risk assessment and had prognostic interactions with FFR and treatment modalities. Therefore, they need to be integrated into risk stratification and the optimisation of a treatment strategy. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Société Europa édition | - |
dc.relation.isPartOf | EUROINTERVENTION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Computed Tomography Angiography | - |
dc.subject.MESH | Coronary Angiography / methods | - |
dc.subject.MESH | Coronary Artery Disease* / diagnostic imaging | - |
dc.subject.MESH | Coronary Artery Disease* / pathology | - |
dc.subject.MESH | Coronary Artery Disease* / therapy | - |
dc.subject.MESH | Coronary Stenosis* / therapy | - |
dc.subject.MESH | Coronary Vessels / pathology | - |
dc.subject.MESH | Fractional Flow Reserve, Myocardial* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Percutaneous Coronary Intervention* | - |
dc.subject.MESH | Plaque, Atherosclerotic* / diagnostic imaging | - |
dc.subject.MESH | Plaque, Atherosclerotic* / pathology | - |
dc.subject.MESH | Plaque, Atherosclerotic* / therapy | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.title | Outcomes of non-ischaemic coronary lesions with high-risk plaque characteristics on coronary CT angiography | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Seokhun Yang | - |
dc.contributor.googleauthor | Masahiro Hoshino | - |
dc.contributor.googleauthor | Taishi Yonetsu | - |
dc.contributor.googleauthor | Jinlong Zhang | - |
dc.contributor.googleauthor | Doyeon Hwang | - |
dc.contributor.googleauthor | Eun-Seok Shin | - |
dc.contributor.googleauthor | Joon-Hyung Doh | - |
dc.contributor.googleauthor | Chang-Wook Nam | - |
dc.contributor.googleauthor | Jianan Wang | - |
dc.contributor.googleauthor | Shaoliang Chen | - |
dc.contributor.googleauthor | Nobuhiro Tanaka | - |
dc.contributor.googleauthor | Hitoshi Matsuo | - |
dc.contributor.googleauthor | Takashi Kubo | - |
dc.contributor.googleauthor | Hyuk-Jae Chang | - |
dc.contributor.googleauthor | Tsunekazu Kakuta | - |
dc.contributor.googleauthor | Bon-Kwon Koo | - |
dc.identifier.doi | 10.4244/EIJ-D-22-00562 | - |
dc.contributor.localId | A03490 | - |
dc.relation.journalcode | J00800 | - |
dc.identifier.eissn | 1969-6213 | - |
dc.identifier.pmid | 36222756 | - |
dc.identifier.url | https://eurointervention.pcronline.com/article/outcomes-of-non-ischaemic-coronary-lesions-with-high-risk-plaque-characteristics-on-coronary-ct-angiography | - |
dc.contributor.alternativeName | Chang, Hyuck Jae | - |
dc.contributor.affiliatedAuthor | 장혁재 | - |
dc.citation.volume | 18 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1011 | - |
dc.citation.endPage | 1021 | - |
dc.identifier.bibliographicCitation | EUROINTERVENTION, Vol.18(12) : 1011-1021, 2023-01 | - |
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