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Short-Term Outcomes and Cost-Effectiveness between Long-Course Chemoradiation and Short-Course Radiotherapy for Locally Advanced Rectal Cancer
DC Field | Value | Language |
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dc.contributor.author | 금웅섭 | - |
dc.contributor.author | 김남규 | - |
dc.contributor.author | 김태현 | - |
dc.contributor.author | 신상준 | - |
dc.contributor.author | 양승윤 | - |
dc.contributor.author | 장지석 | - |
dc.contributor.author | 조민수 | - |
dc.contributor.author | 배현우 | - |
dc.date.accessioned | 2023-10-19T06:03:13Z | - |
dc.date.available | 2023-10-19T06:03:13Z | - |
dc.date.issued | 2023-06 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196340 | - |
dc.description.abstract | Purpose: Long-course chemoradiotherapy (LCRT) has been widely recommended in a majority of rectal cancer patients. Recently, encouraging data on short-course radiotherapy (SCRT) for rectal cancer has emerged. In this study, we aimed to compare these two methods in terms of short-term outcomes and cost analysis under the Korean medical insurance system. Materials and methods: Sixty-two patients with high-risk rectal cancer, who underwent either SCRT or LCRT followed by total mesorectal excision (TME), were classified into two groups. Twenty-seven patients received 5 Gy×5 with two cycles of XELOX (capecitabine 1000 mg/m² and oxaliplatin 130 mg/m² every 3 weeks) followed by TME (SCRT group). Thirty-five patients received capecitabine-based LCRT followed by TME (LCRT group). Short-term outcomes and cost estimation were assessed between the two groups. Results: Pathological complete response was achieved in 18.5% and 5.7% of patients in the SCRT and LCRT groups, respectively (p=0.223). The 2-year recurrence-free survival rate did not show significant difference between the two groups (SCRT vs. LCRT: 91.9% vs. 76.2%, p=0.394). The average total cost per patient for SCRT was 18% lower for inpatient treatment (SCRT vs. LCRT: $18787 vs. $22203, p<0.001) and 40% lower for outpatient treatment (SCRT vs. LCRT: $11955 vs. $19641, p<0.001) compared to LCRT. SCRT was shown to be the dominant treatment option with fewer recurrences and fewer complications at a lower cost. Conclusion: SCRT was well-tolerated and achieved favorable short-term outcomes. In addition, SCRT showed significant reduction in the total cost of care and distinguished cost-effectiveness compared to LCRT. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Asian People | - |
dc.subject.MESH | Capecitabine / therapeutic use | - |
dc.subject.MESH | Chemoradiotherapy* / methods | - |
dc.subject.MESH | Cost-Benefit Analysis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Neoplasms, Second Primary | - |
dc.subject.MESH | Proctectomy / methods | - |
dc.subject.MESH | Radiotherapy* / methods | - |
dc.subject.MESH | Rectal Neoplasms* / drug therapy | - |
dc.subject.MESH | Rectal Neoplasms* / pathology | - |
dc.subject.MESH | Rectal Neoplasms* / radiotherapy | - |
dc.subject.MESH | Rectal Neoplasms* / surgery | - |
dc.title | Short-Term Outcomes and Cost-Effectiveness between Long-Course Chemoradiation and Short-Course Radiotherapy for Locally Advanced Rectal Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학교실) | - |
dc.contributor.googleauthor | Min Soo Cho | - |
dc.contributor.googleauthor | Hyeon Woo Bae | - |
dc.contributor.googleauthor | Jee Suk Chang | - |
dc.contributor.googleauthor | Seung Yoon Yang | - |
dc.contributor.googleauthor | Tae Hyun Kim | - |
dc.contributor.googleauthor | Woong Sub Koom | - |
dc.contributor.googleauthor | Sang Joon Shin | - |
dc.contributor.googleauthor | Gyu-Seog Choi | - |
dc.contributor.googleauthor | Nam Kyu Kim | - |
dc.identifier.doi | 10.3349/ymj.2023.0042 | - |
dc.contributor.localId | A00273 | - |
dc.contributor.localId | A00353 | - |
dc.contributor.localId | A01082 | - |
dc.contributor.localId | A02105 | - |
dc.contributor.localId | A05359 | - |
dc.contributor.localId | A04658 | - |
dc.contributor.localId | A03817 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 37226566 | - |
dc.subject.keyword | Rectal cancer | - |
dc.subject.keyword | cost effectiveness | - |
dc.subject.keyword | long-course chemoradiation | - |
dc.subject.keyword | short course radiotherapy | - |
dc.contributor.alternativeName | Koom, Woong Sub | - |
dc.contributor.affiliatedAuthor | 금웅섭 | - |
dc.contributor.affiliatedAuthor | 김남규 | - |
dc.contributor.affiliatedAuthor | 김태현 | - |
dc.contributor.affiliatedAuthor | 신상준 | - |
dc.contributor.affiliatedAuthor | 양승윤 | - |
dc.contributor.affiliatedAuthor | 장지석 | - |
dc.contributor.affiliatedAuthor | 조민수 | - |
dc.citation.volume | 64 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 395 | - |
dc.citation.endPage | 403 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.64(6) : 395-403, 2023-06 | - |
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