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Association of Metformin Treatment with Risk for Death in Diabetic Patients with Concomitant Gastric Cancer
DC Field | Value | Language |
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dc.contributor.author | 박소희 | - |
dc.contributor.author | 박은철 | - |
dc.date.accessioned | 2023-10-19T05:50:01Z | - |
dc.date.available | 2023-10-19T05:50:01Z | - |
dc.date.issued | 2023-08 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196289 | - |
dc.description.abstract | Importance: Despite the existing guideline's recommendation of metformin therapy as the initial approach for managing diabetes mellitus (DM), there remains a scarcity of comprehensive documentation regarding metformin's impact on outcomes that are important for patients. Objectives: The objective of this study was to assess the potential impact of metformin treatment on the risk of death in individuals diagnosed with both gastric cancer and pre-existing diabetes mellitus (DM); Design, Setting, and Participants: The study made use of a dataset encompassing nationwide health insurance claims, allowing for a retrospective analysis of all patients with a history of gastric cancer diagnosis (classified under International Classification of Diseases 10th Revision code: C16.X) spanning from 1 January 2002 to 31 December 2012. The primary objective was to observe death within a 5-year follow-up period. The study population comprised 63,664 individuals who fell into two categories: those treated with metformin (n = 29,548) and those who did not receive metformin treatment (n = 34,116). This classification was based on the initial treatment allocation following the diagnosis of gastric cancer. Exposures: Metformin treatment, comorbidities, concurrent medication, and procedural information. Outcomes: All-cause death, disease-specific death, cardiovascular death. Results: During the 5-year follow-up period, the metformin treatment group exhibited a lower cumulative incidence of all-cause death (27.5%) in comparison to the group not receiving metformin treatment (32.8%). Furthermore, the relative hazards for all-cause death were significantly reduced in the metformin treatment group (HR: 0.80, 95% CI 0.78-0.82), indicating a lower risk of death when compared to the non-metformin group. In addition, metformin treatment was associated with lower occurrences of disease-specific death (related to gastric cancer) and cardiovascular death when compared to the group not undergoing metformin treatment. Conclusions: The findings demonstrated that the use of metformin was effective at improving prognosis among gastric cancer patients documented with prior DM. In this population-based cohort study, metformin treatment was associated with reduced risk of mortality. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | CANCERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Association of Metformin Treatment with Risk for Death in Diabetic Patients with Concomitant Gastric Cancer | - |
dc.type | Article | - |
dc.contributor.college | Graduate School of Public Health (보건대학원) | - |
dc.contributor.department | Graduate School of Public Health (보건대학원) | - |
dc.contributor.googleauthor | Jae-Hong Joo | - |
dc.contributor.googleauthor | Hyun-Soo Zhang | - |
dc.contributor.googleauthor | Jiyeon Chun | - |
dc.contributor.googleauthor | Eun-Cheol Park | - |
dc.contributor.googleauthor | Sohee Park | - |
dc.identifier.doi | 10.3390/cancers15164134 | - |
dc.contributor.localId | A01531 | - |
dc.contributor.localId | A01618 | - |
dc.relation.journalcode | J03449 | - |
dc.identifier.eissn | 2072-6694 | - |
dc.identifier.pmid | 37627162 | - |
dc.subject.keyword | all-cause death | - |
dc.subject.keyword | diabetes mellitus | - |
dc.subject.keyword | gastric cancer | - |
dc.subject.keyword | metformin | - |
dc.contributor.alternativeName | Park, So Hee | - |
dc.contributor.affiliatedAuthor | 박소희 | - |
dc.contributor.affiliatedAuthor | 박은철 | - |
dc.citation.volume | 15 | - |
dc.citation.number | 16 | - |
dc.citation.startPage | 4134 | - |
dc.identifier.bibliographicCitation | CANCERS, Vol.15(16) : 4134, 2023-08 | - |
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