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Trends in HOMA-IR values among South Korean adolescents from 2007-2010 to 2019-2020: a sex-, age-, and weight status-specific analysis
DC Field | Value | Language |
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dc.contributor.author | 권아름 | - |
dc.contributor.author | 김호성 | - |
dc.contributor.author | 서정환 | - |
dc.contributor.author | 송경철 | - |
dc.contributor.author | 채현욱 | - |
dc.contributor.author | 김수진 | - |
dc.contributor.author | 이명섭 | - |
dc.date.accessioned | 2023-10-19T05:40:54Z | - |
dc.date.available | 2023-10-19T05:40:54Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 0307-0565 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/196240 | - |
dc.description.abstract | Background/objectives: An increase in obesity prevalence may lead to an increase in the HOMA-IR value. This study aimed to investigate changes in age- and sex-specific homeostasis model assessment of insulin resistance (HOMA-IR) values among South Korean adolescents, using data from the Korean National Health and Nutrition Examination Survey (KNHANES) IV, V, and VIII conducted between 2007-2010 and 2019-2020. Subjects/methods: Overall, 4621 adolescents aged 10-18 years were evaluated, including 3473 from the 2007-2010 dataset and 1148 from the 2019-2020 dataset. The mean HOMA-IR values and percentile curves were evaluated by age, sex, and weight status. Results: The mean HOMA-IR values peaked at puberty in both sexes and further increased during puberty in the 2019-2020 dataset (boys 5.21, 95% confidence interval [CI] 4.16-6.26; girls 5.21, 95% CI 3.09-7.33) compared with the 2007-2010 dataset (boys 3.25, 95% CI 3.04-3.47; girls 3.58, 95% CI 3.31-3.85). Both groups (with normal-weight and overweight/obesity) exhibited a peak HOMA-IR value during puberty in both sexes and both datasets, although the group with overweight/obesity had a higher and wider peak age range. While the mean HOMA-IR values did not change in adolescents with normal-weight, they increased during puberty and post-puberty in boys with overweight/obesity. Conclusions: HOMA-IR values should be interpreted considering sex, weight status, and pubertal stages. In particular, during the pubertal period, insulin resistance (IR) can coexist not only due to weight-related factors but also as a result of the distinct hormonal changes characteristic of puberty. Over the 10-year period, the mean HOMA-IR values increased in the group with overweight/obesity during puberty and post-puberty, highlighting the need for active intervention to prevent metabolic complications in adolescents with overweight/obesity. © 2023. The Author(s). | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Nature Pub. Group | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF OBESITY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Body Mass Index | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Insulin Resistance* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Nutrition Surveys | - |
dc.subject.MESH | Obesity / epidemiology | - |
dc.subject.MESH | Obesity / metabolism | - |
dc.subject.MESH | Overweight / epidemiology | - |
dc.subject.MESH | Republic of Korea / epidemiology | - |
dc.title | Trends in HOMA-IR values among South Korean adolescents from 2007-2010 to 2019-2020: a sex-, age-, and weight status-specific analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | Sujin Kim | - |
dc.contributor.googleauthor | Kyungchul Song | - |
dc.contributor.googleauthor | Myeongseob Lee | - |
dc.contributor.googleauthor | Junghwan Suh | - |
dc.contributor.googleauthor | Hyun Wook Chae | - |
dc.contributor.googleauthor | Ho-Seong Kim | - |
dc.contributor.googleauthor | Ahreum Kwon | - |
dc.identifier.doi | 10.1038/s41366-023-01340-2 | - |
dc.contributor.localId | A00228 | - |
dc.contributor.localId | A01184 | - |
dc.contributor.localId | A05629 | - |
dc.contributor.localId | A06013 | - |
dc.contributor.localId | A04026 | - |
dc.relation.journalcode | J01140 | - |
dc.identifier.eissn | 1476-5497 | - |
dc.identifier.pmid | 37443273 | - |
dc.contributor.alternativeName | Kwon, Ah Reum | - |
dc.contributor.affiliatedAuthor | 권아름 | - |
dc.contributor.affiliatedAuthor | 김호성 | - |
dc.contributor.affiliatedAuthor | 서정환 | - |
dc.contributor.affiliatedAuthor | 송경철 | - |
dc.contributor.affiliatedAuthor | 채현욱 | - |
dc.citation.volume | 47 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 865 | - |
dc.citation.endPage | 872 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF OBESITY, Vol.47(9) : 865-872, 2023-09 | - |
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