Cited 9 times in
Prognostic Impact of Elective Supraclavicular Nodal Irradiation for Patients with N1 Breast Cancer after Lumpectomy and Anthracycline Plus Taxane-Based Chemotherapy (KROG 1418): A Multicenter Case-Controlled Study
DC Field | Value | Language |
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dc.contributor.author | 김용배 | - |
dc.date.accessioned | 2023-08-09T02:35:11Z | - |
dc.date.available | 2023-08-09T02:35:11Z | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195648 | - |
dc.description.abstract | Purpose: This study was conducted to evaluate the impact of supraclavicular lymph node radiotherapy (SCNRT) on N1 breast cancer patients receiving post-lumpectomy whole-breast irradiation (WBI) and anthracycline plus taxane-based (AT) chemotherapy. Materials and methods: We performed a case-control analysis to compare the outcomes of WBI and WBI plus SCNRT (WBI+SCNRT). Among 1,147 patients with N1 breast cancer who received post-lumpectomy radiotherapy and AT-based chemotherapy in 12 hospitals, 542 were selected after propensity score matching. Patterns of failure, disease-free survival (DFS), distant metastasis-free survival (DMFS), and treatment-related toxicity were compared between groups. Results: A total of 41 patients (7.6%) were found to have recurrence. Supraclavicular lymph node (SCN) failure was detected in three patients, two in WBI and one in WBI+SCNRT. All SCN failures were found simultaneously with distant metastasis. There was no significant difference in patterns of failure or survival between groups. The 5-year DFS and DMFS for patients with WBI and WBI+SCNRT were 94.4% versus 92.6% (p=0.50) and 95.1% versus 94.5% (p=0.99), respectively. The rates of lymphedema and radiation pneumonitis were significantly higher in the WBI+SCNRT than in the WBI. Conclusion: We did not find a benefit of SCNRT for N1 breast cancer patients receiving AT-based chemotherapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English, Korean | - |
dc.publisher | Official journal of Korean Cancer Association | - |
dc.relation.isPartOf | CANCER RESEARCH AND TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Anthracyclines / administration & dosage | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols / adverse effects | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols / therapeutic use | - |
dc.subject.MESH | Breast Neoplasms / mortality* | - |
dc.subject.MESH | Breast Neoplasms / pathology | - |
dc.subject.MESH | Breast Neoplasms / radiotherapy* | - |
dc.subject.MESH | Bridged-Ring Compounds / administration & dosage | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Combined Modality Therapy | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymphatic Metastasis | - |
dc.subject.MESH | Mastectomy, Segmental | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Postoperative Care* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Radiotherapy Dosage | - |
dc.subject.MESH | Radiotherapy, Adjuvant | - |
dc.subject.MESH | Survival Analysis | - |
dc.subject.MESH | Taxoids / administration & dosage | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Prognostic Impact of Elective Supraclavicular Nodal Irradiation for Patients with N1 Breast Cancer after Lumpectomy and Anthracycline Plus Taxane-Based Chemotherapy (KROG 1418): A Multicenter Case-Controlled Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학교실) | - |
dc.contributor.googleauthor | Haeyoung Kim | - |
dc.contributor.googleauthor | Won Park | - |
dc.contributor.googleauthor | Jeong Il Yu | - |
dc.contributor.googleauthor | Doo Ho Choi | - |
dc.contributor.googleauthor | Seung Jae Huh | - |
dc.contributor.googleauthor | Yeon-Joo Kim | - |
dc.contributor.googleauthor | Eun Sook Lee | - |
dc.contributor.googleauthor | Keun Seok Lee | - |
dc.contributor.googleauthor | Han-Sung Kang | - |
dc.contributor.googleauthor | In Hae Park | - |
dc.contributor.googleauthor | Kyung Hwan Shin | - |
dc.contributor.googleauthor | Chan Woo Wee | - |
dc.contributor.googleauthor | Kyubo Kim | - |
dc.contributor.googleauthor | Kyung Ran Park | - |
dc.contributor.googleauthor | Yong Bae Kim | - |
dc.contributor.googleauthor | Sung Ja Ahn | - |
dc.contributor.googleauthor | Jong Hoon Lee | - |
dc.contributor.googleauthor | Jin Hee Kim | - |
dc.contributor.googleauthor | Mison Chun | - |
dc.contributor.googleauthor | Hyung-Sik Lee | - |
dc.contributor.googleauthor | Jung Soo Kim | - |
dc.contributor.googleauthor | Jihye Cha | - |
dc.identifier.doi | 10.4143/crt.2016.382 | - |
dc.contributor.localId | A00744 | - |
dc.relation.journalcode | J00453 | - |
dc.identifier.eissn | 2005-9256 | - |
dc.identifier.pmid | 28052649 | - |
dc.subject.keyword | Adjuvant radiotherapy | - |
dc.subject.keyword | Breast neoplasms | - |
dc.subject.keyword | Case-control studies | - |
dc.subject.keyword | Lymphatic irradiation | - |
dc.subject.keyword | Taxane | - |
dc.contributor.alternativeName | Kim, Yong Bae | - |
dc.contributor.affiliatedAuthor | 김용배 | - |
dc.citation.volume | 49 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 970 | - |
dc.citation.endPage | 980 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, Vol.49(4) : 970-980, 2017-10 | - |
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