Cited 3 times in
Bone morphogenetic protein-7 attenuates pancreatic damage under diabetic conditions and prevents progression to diabetic nephropathy via inhibition of ferroptosis
DC Field | Value | Language |
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dc.contributor.author | 구민희 | - |
dc.contributor.author | 김남희 | - |
dc.contributor.author | 김현실 | - |
dc.contributor.author | 양재문 | - |
dc.contributor.author | 유태현 | - |
dc.contributor.author | 육종인 | - |
dc.contributor.author | 한다울 | - |
dc.contributor.author | 김성훈 | - |
dc.date.accessioned | 2023-07-12T03:08:54Z | - |
dc.date.available | 2023-07-12T03:08:54Z | - |
dc.date.issued | 2023-05 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195522 | - |
dc.description.abstract | Background: Approximately 30% of diabetic patients develop diabetic nephropathy, a representative microvascular complication. Although the etiological mechanism has not yet been fully elucidated, renal tubular damage by hyperglycemia-induced expression of transforming growth factor-β (TGF-β) is known to be involved. Recently, a new type of cell death by iron metabolism called ferroptosis was reported to be involved in kidney damage in animal models of diabetic nephropathy, which could be induced by TGF-β. Bone morphogenetic protein-7 (BMP7) is a well-known antagonist of TGF-β inhibiting TGF-β-induced fibrosis in many organs. Further, BMP7 has been reported to play a role in the regeneration of pancreatic beta cells in diabetic animal models. Methods: We used protein transduction domain (PTD)-fused BMP7 in micelles (mPTD-BMP7) for long-lasting in vivo effects and effective in vitro transduction and secretion. Results: mPTD-BMP7 successfully accelerated the regeneration of diabetic pancreas and impeded progression to diabetic nephropathy. With the administration of mPTD-BMP7, clinical parameters and representative markers of pancreatic damage were alleviated in a mouse model of streptozotocin-induced diabetes. It not only inhibited the downstream genes of TGF-β but also attenuated ferroptosis in the kidney of the diabetic mouse and TGF-β-stimulated rat kidney tubular cells. Conclusion: BMP7 impedes the progression of diabetic nephropathy by inhibiting the canonical TGF-β pathway, attenuating ferroptosis, and helping regenerate diabetic pancreas. Copyright © 2028 Song, Han, Park, Um, Kim, Ku, Yang, Yoo, Yook, Kim and Kim. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Frontiers Research | - |
dc.relation.isPartOf | FRONTIERS IN ENDOCRINOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Diabetes Mellitus | - |
dc.subject.MESH | Experimental* / complications | - |
dc.subject.MESH | Diabetes Mellitus | - |
dc.subject.MESH | Experimental* / metabolism | - |
dc.subject.MESH | Diabetic Nephropathies* / genetics | - |
dc.subject.MESH | Diabetic Nephropathies* / metabolism | - |
dc.subject.MESH | Ferroptosis* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Pancreas / metabolism | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Transforming Growth Factor beta / metabolism | - |
dc.title | Bone morphogenetic protein-7 attenuates pancreatic damage under diabetic conditions and prevents progression to diabetic nephropathy via inhibition of ferroptosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Sang Hyun Song | - |
dc.contributor.googleauthor | Dawool Han | - |
dc.contributor.googleauthor | Kyeonghui Park | - |
dc.contributor.googleauthor | Jo Eun Um | - |
dc.contributor.googleauthor | Seonghun Kim | - |
dc.contributor.googleauthor | Minhee Ku | - |
dc.contributor.googleauthor | Jaemoon Yang | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.contributor.googleauthor | Jong In Yook | - |
dc.contributor.googleauthor | Nam Hee Kim | - |
dc.contributor.googleauthor | Hyun Sil Kim | - |
dc.identifier.doi | 10.3389/fendo.2023.1172199 | - |
dc.contributor.localId | A00191 | - |
dc.contributor.localId | A00360 | - |
dc.contributor.localId | A01121 | - |
dc.contributor.localId | A02315 | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A02536 | - |
dc.relation.journalcode | J03412 | - |
dc.identifier.eissn | 1664-2392 | - |
dc.identifier.pmid | 37293506 | - |
dc.subject.keyword | Bmp12 | - |
dc.subject.keyword | TGF-β | - |
dc.subject.keyword | diabetic nephropathy | - |
dc.subject.keyword | ferroptosis | - |
dc.subject.keyword | fibrosis | - |
dc.contributor.alternativeName | Ku, Min Hee | - |
dc.contributor.affiliatedAuthor | 구민희 | - |
dc.contributor.affiliatedAuthor | 김남희 | - |
dc.contributor.affiliatedAuthor | 김현실 | - |
dc.contributor.affiliatedAuthor | 양재문 | - |
dc.contributor.affiliatedAuthor | 유태현 | - |
dc.contributor.affiliatedAuthor | 육종인 | - |
dc.citation.volume | 14 | - |
dc.citation.startPage | 1172199 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN ENDOCRINOLOGY, Vol.14 : 1172199, 2023-05 | - |
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