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Topical Application of Peptide Nucleic Acid Antisense Oligonucleotide for MMP-1 and Its Potential Anti-Aging Properties
DC Field | Value | Language |
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dc.contributor.author | 이영인 | - |
dc.contributor.author | 이주희 | - |
dc.date.accessioned | 2023-07-12T02:53:19Z | - |
dc.date.available | 2023-07-12T02:53:19Z | - |
dc.date.issued | 2023-03 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/195433 | - |
dc.description.abstract | Matrix metalloproteinase-1 (MMP-1) is a zinc-containing endopeptidase that degrades dermal collagen and other extracellular matrix molecules. It is recognized as one of the most important indicators of cellular senescence and age-related skin changes. Here, we introduced a novel MMP-1 peptide nucleic acid (PNA) derivative—PNA-20 carboxyethyl fluorene (CEF)—which can interact with and consequently silence the MMP-1 gene sequence. The investigation on the efficacy of PNA-20 CEF in MMP-1 silencing in human dermal fibroblasts revealed significantly decreased expression of MMP-1 at both gene and protein levels. Treatment with PNA-20 CEF showed significantly increased expression of collagen I protein, indicating its potential role in preventing the degradation of collagen I and consequently combating the skin aging process. Its topical application on 3D human skin tissue showed successful absorption into the epidermis and the upper dermis. Furthermore, the additional 4-week single-arm prospective study on 21 Asian women revealed improvements in facial wrinkles, skin moisture, elasticity, and density after the use of the topical PNA-20 CEF cosmeceutical formulation. Additional in-vitro and ex-vivo studies are needed for a comprehensive understanding of the skin anti-aging effects of MMP-1 PNA. © 2023 by the authors. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Topical Application of Peptide Nucleic Acid Antisense Oligonucleotide for MMP-1 and Its Potential Anti-Aging Properties | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학교실) | - |
dc.contributor.googleauthor | Young In Lee | - |
dc.contributor.googleauthor | Sang Gyu Lee | - |
dc.contributor.googleauthor | Inhee Jung | - |
dc.contributor.googleauthor | Jangmi Suk | - |
dc.contributor.googleauthor | Chaemin Baeg | - |
dc.contributor.googleauthor | Seon-Young Han | - |
dc.contributor.googleauthor | Jeong Yeon Seo | - |
dc.contributor.googleauthor | Daram Jung | - |
dc.contributor.googleauthor | Yeasel Jeon | - |
dc.contributor.googleauthor | Ju Hee Lee | - |
dc.identifier.doi | 10.3390/jcm12072472 | - |
dc.contributor.localId | A05880 | - |
dc.contributor.localId | A03171 | - |
dc.relation.journalcode | J03556 | - |
dc.identifier.eissn | 2077-0383 | - |
dc.identifier.pmid | 37048555 | - |
dc.subject.keyword | PNA-20 CEF | - |
dc.subject.keyword | anti-aging | - |
dc.subject.keyword | collagen I | - |
dc.subject.keyword | matrix metalloproteinase-1 | - |
dc.subject.keyword | peptide nucleic acid | - |
dc.contributor.alternativeName | Lee, Young In | - |
dc.contributor.affiliatedAuthor | 이영인 | - |
dc.contributor.affiliatedAuthor | 이주희 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 2472 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, Vol.12(7) : 2472, 2023-03 | - |
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