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Marked Reduction in the Risk of Dementia in Patients with Breast Cancer: A Nationwide Population-Based Cohort Study

Authors
 Jooyoung Oh  ;  Hye Sun Lee  ;  Soyoung Jeon  ;  Jeong-Ho Seok  ;  Tae-Kyung Yoo  ;  Woo-Chan Park  ;  Chang Ik Yoon 
Citation
 CANCER RESEARCH AND TREATMENT, Vol.55(2) : 551-561, 2023-04 
Journal Title
CANCER RESEARCH AND TREATMENT
ISSN
 1598-2998 
Issue Date
2023-04
MeSH
Breast Neoplasms* / drug therapy ; Breast Neoplasms* / epidemiology ; Cataract* / epidemiology ; Cohort Studies ; Dementia* / diagnosis ; Dementia* / epidemiology ; Dementia* / etiology ; Female ; Humans ; Incidence ; Middle Aged ; Neurodegenerative Diseases* ; Retrospective Studies ; Risk Factors
Keywords
Breast neoplams ; Dementia ; Incidence ; Neurodegenerative diseases ; Risk
Abstract
Purpose: An inverse relationship between cancer and neurodegenerative disease, which presents the possibility of a reduced risk of dementia in cancer patients, has been suggested previously. However, a nationwide longitudinal population-based study of specific types of cancer with due consideration of treatment effects has not been conducted.

Materials and Methods: This nationwide population-based cohort study used data obtained in a 12-year period (January 2007- December 2018) in the Korean National Health Insurance claims database. All female breast cancer patients (age ≥ 50 years) diagnosed between 2009 and 2010 were included after excluding those with physician visits for any cancer during a 2-year period (2007-2008). Patients with senile cataract constituted the control group. The main study outcome was the risk of developing dementia.

Results: From a total of 90,396 and 85,906 patients with breast cancer and cataract, respectively, patients without behavior codes were excluded. Data for 15,407 breast cancer patients and 7,020 controls were analyzed before matching. After matching for comorbidities and age, either group comprised 2,252 patients. The median follow-up time was 104.1±24.0 months after matching. After matching, breast cancer was a predictor of a lower risk of for dementia (hazard ratio, 0.091; 95% confidence interval, 0.075 to 0.111; p < 0.001). In breast cancer patients, receiving chemotherapy and endocrine therapy did not significantly affect the incidence of dementia.

Conclusion: Breast cancer was associated with a remarkably decreased risk of dementia. The findings strongly suggest an inverse relationship between cancer and neurodegeneration, regardless of the adverse effects of cancer treatment on cognitive function.
Files in This Item:
T202302946.pdf Download
DOI
10.4143/crt.2022.272
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Seok, Jeong Ho(석정호) ORCID logo https://orcid.org/0000-0002-9402-7591
Oh, Jooyoung(오주영) ORCID logo https://orcid.org/0000-0001-6721-399X
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/195326
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